915210-50-3

915210-50-3 structure

Name: SCH-900271
Chemical Name: 5-[3-(1-methylcyclopropyl)propyl]-1H-pyrano[2,3-d]pyrimidine-2,4,7-trione
CAS Number: 915210-50-3
Molecular Formula: C₁₄H₁₆N₂O₄
Molecular Weight: 276.28800
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2017-03-01 05:14:00
Modify Date: 2024-09-19 06:46:13
SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC50 of 2 nM in the hu-GPR109a assay. SCH-900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA). SCH-900271 has an improved therapeutic window to flushing[1].

Name	5-[3-(1-methylcyclopropyl)propyl]-1H-pyrano[2,3-d]pyrimidine-2,4,7-trione
Synonyms	unii-g2283xq6vj

Description	SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC50 of 2 nM in the hu-GPR109a assay. SCH-900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA). SCH-900271 has an improved therapeutic window to flushing[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Metabolic Disease
Target	EC50: 2.0 nM (hu-GPR109a), 96 nM (hu-GPR109b), 8.0 nM (rat-GPR109a), 6.0 nM (m-GPR109a) and 5.0 nM (dog-GPR109a)[1]
References	[1]. Anandan Palani, et al. Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8.