19031-57-3

19031-57-3 structure

Name: Suberic acid-d4
Chemical Name: 1,8-octanedioic-2,2,7,7-d4 acid
CAS Number: 19031-57-3
Molecular Formula: C₈H₁₀D₄O₄
Molecular Weight: 178.21900
Catalog: Research Areas Metabolic Disease
Create Date: 2018-06-28 18:53:26
Modify Date: 2024-01-05 16:31:23
Suberic acid-d4 is the deuterium labeled Suberic acid[1]. Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency[2].

Name	1,8-octanedioic-2,2,7,7-d4 acid
Synonyms	2,2,7,7-tetradeuterio-octanedioic acid 1,2-dichloroisopropylbenzene <2,7-2H4>-Octandisaeure 1,2-dichloro-2-phenylpropane 1,2-Dichlor-2-phenylpropan

Description	Suberic acid-d4 is the deuterium labeled Suberic acid[1]. Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency[2].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Gregersen N, et al. General (medium-chain) acyl-CoA dehydrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases. Clin Chim Acta. 1983 Aug 15;132(2):181-91.