477-85-0

477-85-0 structure

Name: Obtusifolin
Chemical Name: 2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione
CAS Number: 477-85-0
Molecular Formula: C₁₆H₁₂O₅
Molecular Weight: 284.263
Catalog: Organic raw materials Terpenoid
Create Date: 2018-03-26 08:00:00
Modify Date: 2024-01-07 18:58:47
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2].

Name	2,8-dihydroxy-1-methoxy-3-methylanthracene-9,10-dione
Synonyms	Anthraquinone,2,8-dihydroxy-1-methoxy-3-methyl 2,8-dihydroxy-1-methoxy-3-methyl-anthraquinone Anthraquinone, 2,8-dihydroxy-1-methoxy-3-methyl- 9,10-Anthracenedione, 2,8-dihydroxy-1-methoxy-3-methyl- 2,8-Dihydroxy-1-methoxy-3-methyl-anthrachinon obtusifoline Obtusifolin (anthraquinone) 1,7-Dihydroxy-8-methoxy-6-methyl-9,10-anthraquinone 2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthraquinone Obtusifolin 2,8-dihydroxy-1-methoxy-3-methylanhraquinone 2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthracenedione

Description	Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2].
Related Catalog	Research Areas >> Cancer
Target	NF-κB
In Vitro	Obtusifolin (1, 10, 100 μM) inhibits MUC5AC gene expression induced by EGF, PMA, or TNF-α in NCI-H292 cells[1].
References	[1]. Choi BS, et al. Obtusifolin isolated from the seeds of Cassia obtusifolia regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via affecting NF-κB pathway. Phytother Res. 2019 Apr;33(4):919-928. [2]. Hsu YL, et al. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. J Agric Food Chem. 2014 Dec 10;62(49):11933-40.

108637-81-6

~0%

477-85-0

58322-78-4

Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002

108637-71-4

477-85-0

Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002

127042-39-1

~98%

477-85-0

Literature: Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 - 5176

108637-77-0

~60%

477-85-0

58322-78-4

Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002

108637-73-6

477-85-0

Literature: Cameron, Donald W.; Feutrill, Geoffrey I.; Gamble, Glenn B.; Stavrakis, John Tetrahedron Letters, 1986 , vol. 27, # 41 p. 4999 - 5002

71700-71-5

477-85-0

Literature: Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 - 5176

72476-03-0

477-85-0

Literature: Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 - 5176

127042-37-9

477-85-0

Literature: Camerom, Donald W.; Feutrill, Geoffrey I.; Keep, Philip L. C. Tetrahedron Letters, 1989 , vol. 30, # 38 p. 5173 - 5176

481-39-0

108637-73-6

477-85-0

Literature: Krohn, Carsten; Khanbabaee, Karamali Liebigs Annalen der Chemie, 1993 , # 8 p. 905 - 910