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100853-58-5

100853-58-5 structure
100853-58-5 structure

Name h-thr-thr-tyr-ala-asp-phe-ile-ala-ser-gly-arg-thr-gly-arg-arg-asn-ala-ile-nh2
Synonyms PKI (5-22),AMIDE
CAMP-DEPENDENT PROTEIN KINASE INHIBITOR (5-22) AMIDE
PKI-a (5-22) aMide (huMan,Mouse,rabbit,rat),Wiptide
cAMP-Dependent Protein Kinase Inhibitor (5-22),amide,Wiptide
WIPTIDE
PROTEIN KINASE A INHIBITOR (5-22) AMIDE
TTYADFIASGRTGRRNAI-NH2
CAMP DEPENDENT PK INHIBITOR (5-22) AMIDE
PKA INHIBITOR (5-22) AMIDE
THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2
THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-HIS-ASP: TTYADFIASGRTGRRNAIHD
Description PKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors[1][2].
Related Catalog
In Vitro PKI(5-22)amide (1 μM; 1 min) fails to block CRF1 receptor (100 nM; 30 min) desensitization in Y-79 cells permeabilized with Streptolysin O (HY-135416)[1].
References

[1]. Dautzenberg FM, et al. GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation. Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R935-46.  

[2]. Reed J, et al. Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase. Biochem J. 1989 Dec 1;264(2):371-80.  

Molecular Formula C84H137N29O26
Molecular Weight 1969.17000
Exact Mass 1968.03000
PSA 931.05000