57998-68-2

57998-68-2 structure

Name: Carbamic acid,N,N'-[2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-diyl]bis-,C,C'-diethyl ester
Chemical Name: ethyl N-[2,5-bis(aziridin-1-yl)-4-(ethoxycarbonylamino)-3,6-dioxocyclohexa-1,4-dien-1-yl]carbamate
CAS Number: 57998-68-2
Molecular Formula: C₁₆H₂₀N₄O₆
Molecular Weight: 364.35300
Catalog: Research Areas Cancer
Create Date: 2018-08-31 23:03:30
Modify Date: 2024-01-13 17:33:48
Diaziquone (Diaziquone) is a water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity[1].

Name	ethyl N-[2,5-bis(aziridin-1-yl)-4-(ethoxycarbonylamino)-3,6-dioxocyclohexa-1,4-dien-1-yl]carbamate
Synonyms	AZQ 2,5-di(aziridin-1-yl)-3,6-bis(carboethoxyamino)-1,4-benzoquinone 3,6-bis<(ethylcarboxy)amino>-2,5-diaziridinyl-1,4-benzoquinone 2,5-diaziridinyl-3,6-bis(carboethoxy-amino)-1,4-benzoquinone diaziquone CI-904 Diaziquonum [INN-Latin] Aziridinylquinone Aziridinylbenzoquinone

Description	Diaziquone (Diaziquone) is a water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vivo	Diaziquone (6.75mg /sq m daily for 5 consecutive days or single-dose 26 mg/sq m) has a broad range of activity of diaziquone against primary nervous system tumors and has enhancement effect combined with either 1,3-bis(2-chloroethyl)-1-nitrosourea or procarbazine in athymic mice[1]. Animal Model: Homozygous nu/nu BALB/c athymic mice[1] Dosage: 6.75mg /sq m or 26 mg/sq m Administration: 6.75mg /sq m daily for 5 consecutive days or single-dose 26 mg/sq m Result: Showed rapid clearance in the plasma of athymic mice with a half-life of approximately 11.5 min. Produced significant growth delays. Produced significant increases in the median growth delay, significant increases in the number of tumor regressions.

Density	1.45g/cm3
Boiling Point	469ºC at 760mmHg
Molecular Formula	C₁₆H₂₀N₄O₆
Molecular Weight	364.35300
Flash Point	237.4ºC
Exact Mass	364.13800
PSA	116.82000
LogP	0.34240
Index of Refraction	1.62

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EY8794000

CHEMICAL NAME :: Carbamic acid, (2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadien-1, 4-diyl)bis-, diethyl ester

CAS REGISTRY NUMBER :: 57998-68-2

BEILSTEIN REFERENCE NO. :: 1333277

LAST UPDATED :: 199612

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C16-H20-N4-O6

MOLECULAR WEIGHT :: 364.40

WISWESSER LINE NOTATION :: L6V DV AU DUTJ BMVO2 C- AT3NTJ& EMVO2 F- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11290 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10300 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1550 ug/kg/5D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2400 ug/kg/33D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 6250 ug/kg/5D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Blood - changes in spleen

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 300 nmol/L

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,322,1983