122929-08-2

122929-08-2 structure

Name: Corazonin
Chemical Name: corazonin
CAS Number: 122929-08-2
Molecular Formula: C₆₂H₈₄N₁₈O₁₈
Molecular Weight: 1369.44000
Catalog: Biochemical Peptide
Create Date: 2018-02-25 08:00:00
Modify Date: 2024-01-14 19:59:13
Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects, serves a central regulator of caste identity and behavior in social insects. Corazonin is also preferentially expressed in workers and/or foragers from other social insect species[1][2].

Name	corazonin
Synonyms	PYR-TFQYSRGWTN-NH2 GLP-THR-PHE-GLN-TYR-SER-ARG-GLY-TRP-THR-ASN-NH2 PGLU-THR-PHE-GLN-TYR-SER-ARG-GLY-TRP-THR-ASN-NH2 PYR-THR-PHE-GLN-TYR-SER-ARG-GLY-TRP-THR-ASN-NH2 MFCD00133199

Description	Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects, serves a central regulator of caste identity and behavior in social insects. Corazonin is also preferentially expressed in workers and/or foragers from other social insect species[1][2].
Related Catalog	Research Areas >> Neurological Disease
In Vitro	Corazonin 是由侧脑神经分泌细胞投射到心体-语料体复合体和腹侧神经束神经元中产生的[1]。 Corazonin 在卵母细胞中激发内向电流 (EC50=200 pM)，并导致 CHO细胞的发光响应 (EC50=75 pM)[1]。
In Vivo	Corazonin (5.4 ng/脑室; 注射法; 单剂量) 在过渡期的哈氏牙鲆个体中，抑制大脑中卵黄蛋白原的表达，并刺激类似工人的狩猎行为，同时抑制决斗和卵子沉积等斗兽类行为[2]。
References	[1]. Kim YJ, et al. Corazonin receptor signaling in ecdysis initiation. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6704-9. [2]. Gospocic J, et al. The Neuropeptide Corazonin Controls Social Behavior and Caste Identity in Ants. Cell. 2017 Aug 10;170(4):748-759.e12.

WGK Germany	3