10180-86-6

10180-86-6 structure

Name: Azuleno[6,5-b]furan-2,5-dione,4-(acetyloxy)-3,3a,4,4a,7a,8,9,9a-octahydro-4a,8-dimethyl-3-methylene-,(3aR,4S,4aR,7aR,8R,9aR)-
Chemical Name: [(3aR,5R,5aR,8aR,9S,9aR)-5,8a-dimethyl-1-methylidene-2,8-dioxo-3a,4,5,5a,9,9a-hexahydroazuleno[6,5-b]furan-9-yl] acetate
CAS Number: 10180-86-6
Molecular Formula: C₁₇H₂₀O₅
Molecular Weight: 304.33800
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2017-12-04 16:03:48
Modify Date: 2024-01-14 19:04:43
Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities[1].

Name	[(3aR,5R,5aR,8aR,9S,9aR)-5,8a-dimethyl-1-methylidene-2,8-dioxo-3a,4,5,5a,9,9a-hexahydroazuleno[6,5-b]furan-9-yl] acetate
Synonyms	6-O-acetylhelenalin Helenalin acetate Helenalin 6-acetate Angustibalin HELANIN ACETATE O-Acetyl-helenalin acetylhelenalin

Description	Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase Research Areas >> Inflammation/Immunology
In Vitro	Helenalin acetate（0.1-1 μM；持续 7 天）显着抑制 3T3-L1 细胞的分化[1]。 Helenalin acetate对急性髓性白血病细胞具有抗增殖作用，对正常造血祖细胞无作用[1]。 Helenalin acetate 通过结合到 C/EBPβ 的 N 末端部分来抑制 C/EBPβ，从而破坏 C/EBPβ 与共激活因子 p300 的合作。Helenalin acetate 仅选择性抑制全长（富含肝脏的激活蛋白* (LAP*)）同种型，但不抑制稍短的 (LAP) 同种型[1]。 Cell Differentiation Assay[1] Cell Line: 3T3-L1 cells Concentration: 0.1 μM, 0.3 μM, 1 μM Incubation Time: for 7 days Result: Inhibited the differentiation significantly.
References	[1]. Jakobs A, et al. Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300. J Biol Chem. 2016 Dec 9;291(50):26098-26108.