263399-35-5
263399-35-5 structure
- Name: (9Z)-12,13-Dihydroxy-9-octadecenoic acid
- Chemical Name: (±)12,13-DiHOME
- CAS Number: 263399-35-5
- Molecular Formula: C18H34O4
- Molecular Weight: 314.46
- Catalog: Research Areas Metabolic Disease
- Create Date: 2016-11-21 05:01:51
- Modify Date: 2024-01-09 11:04:31
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12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders[1].
| Name | (±)12,13-DiHOME |
|---|---|
| Synonyms |
cis-12,13-dihydroxy-9-octadecenoic acid
9-Octadecenoic acid, 12,13-dihydroxy-, (9Z)- Monocrotalin-N-oxid (9Z)-12,13-Dihydroxy-9-octadecenoic acid 12,13-dihydroxy-9-octadecenoic acid Monocrotaline,N-oxide |
| Description | 12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders[1]. |
|---|---|
| Related Catalog | |
| In Vivo | 12,13-DiHOME (1 μg/kg；眼球后注射；每天 1 次，共 2 周) 能显著降低小鼠高脂饮食模型中血清甘油三酯水平，并增加 BAT 的摄取以抵御寒冷[1]。 Animal Model: Mice fed a high-fat diet[1] Dosage: 1 μg/kg Administration: Retro-orbitally injection; once daily for 2 weeks Result: Displayed no effects on body weight, glucose tolerance or circulating nonesterified FA. Increased BAT-specific lipid uptake and improved oral lipid tolerance. Increased radiolabeled FA uptake (Fig. 3f) and glucose uptake. Animal Model: To explore the biosynthesis of (±)12, 13-dihome in mice in vivo[1] Dosage: Administration: 7-d cold challenge in mice: mice treated with norepinephrine (NE) for 30 min and exposed to 4°C-cold for 1 h Result: Result: Increased in the circulation of male mice exposed to cold, but not female mice. And also, the enzymes producing 12,13-diHOME were uniquely induced in BAT by cold stimulation. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 476.0±30.0 °C at 760 mmHg |
| Molecular Formula | C18H34O4 |
| Molecular Weight | 314.46 |
| Flash Point | 255.8±21.1 °C |
| Exact Mass | 314.245697 |
| PSA | 77.76000 |
| LogP | 4.14 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.493 |
| Precursor 1 | |
|---|---|
| DownStream 1 | |
