117423-74-2

117423-74-2 structure

Name: LY223982
Chemical Name: [3h]-skf 107324
CAS Number: 117423-74-2
Molecular Formula: C₃₀H₃₀O₇
Molecular Weight: 502.555
Catalog: Signaling Pathways GPCR/G Protein Leukotriene Receptor
Create Date: 2016-11-30 11:38:41
Modify Date: 2024-01-18 03:10:04
LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor.

Name	[3h]-skf 107324
Synonyms	Gonyaulax toxin 3-[3-(2-Carboxyethyl)-4-{[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy}benzoyl]benzoic acid mytiluscalifornianuspoison saxidomusgiganteuspoison SAXITOXIN DIACETATE SALT Benzenepropanoic acid, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]- gonyaulaxcatenellapoison Mussel poison

Description	LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
Target	LTB4:13.2 nM (IC50)
In Vitro	LY223982 is a potent and specific inhibitor of leukotriene B4 (LTB4) receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. LY223982 is also a potent antagonist of the aggregation of human neutrophils by LTB4 (IC50, 100 nM)[1].
In Vivo	LY223982 inhibits transient leukopenia induced in rabbits with LTB4 (ED50, 3 mg/kg) but not with FMLP, and shows no agonist activity in any of the test systems[1].
References	[1]. Jackson WT, et al. Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. J Pharmacol Exp Ther. 1992 Dec;263(3):1009-14.