DC Chemicals Limited
China
Product Name: Mephenoxalone
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: mephenoxalone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

70-07-5

70-07-5 structure

Name: mephenoxalone
Chemical Name: 5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one
CAS Number: 70-07-5
Molecular Formula: C₁₁H₁₃NO₄
Molecular Weight: 223.23
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2018-08-25 11:59:21
Modify Date: 2024-01-02 17:29:44
Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc[1].

Name	5-((2-Methoxyphenoxy)methyl)oxazolidin-2-one
Synonyms	Control-OM 5-[(2-Methoxyphenoxy)methyl]-1,3-oxazolidin-2-one 2-Oxazolidinone, 5-[(2-methoxyphenoxy)methyl]- Mefenoxalona Mefenoxalone EINECS 200-723-3 mephenoxalone 5-({[2-(methyloxy)phenyl]oxy}methyl)-1,3-oxazolidin-2-one Moderamin Methoxydone 5-[(2-Methoxyphenoxy)methyl]-2-oxazolidinone Methoxydon Dorsiflex

Description	Mephenoxalone inhibits neuron transmission and can relax skeletal muscles by inhibiting the reflex arc[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. K F BENITZ, et al. Toxicity studies on mephenoxalone in rats and dogs. Toxicol Appl Pharmacol (IF: 4.22; Q2). 1962 Mar;4:220-37.

Density	1.2±0.1 g/cm3
Boiling Point	440.0±18.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₃NO₄
Molecular Weight	223.23
Flash Point	219.9±21.2 °C
Exact Mass	223.084457
PSA	56.79000
LogP	1.32
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.521

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ3500000

CHEMICAL NAME :: 2-Oxazolidinone, 5-((o-methoxyphenoxy)methyl)-

CAS REGISTRY NUMBER :: 70-07-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C11-H13-N-O4

MOLECULAR WEIGHT :: 223.25

WISWESSER LINE NOTATION :: T5MVOTJ D1OR BO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3820 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,642,1964

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,198,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 11,212,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RAMAAB Revista de la Asociacion Medica Argentina. (Buenos Aires, Argentina) V.1-89, 1915-76. Discontinued. Volume(issue)/page/year: 74,82,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30330 mg/kg/30D-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in ovarian weight

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 18 gm/kg/30D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Liver - other changes Blood - normocytic anemia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 87 gm/kg/26W-I

TOXIC EFFECTS :: Behavioral - ataxia Blood - normocytic anemia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,220,1962

HS Code	2934999090

60420-27-1

870-63-3

~10%

70-07-5

Literature: Smith III, Amos B.; Hirschmann, Ralph F.; Nittoli, Thomas; Sprengeler, Paul Patent: US2002/123635 A1, 2002 ;

124-38-9

943962-56-9

~90%

70-07-5

Literature: Madhusudhan; Reddy, M. Srinivasa; Reddy, Y. Narayana; Vijayalakshmi; Suribabu; Balraju Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 7 p. 978 - 984

590-28-3

25772-81-0

~66%

70-07-5

Literature: Chinnam Naidu; Ravi Babu; Gangaiah; Mukkanti; Madhusudhan Tetrahedron Letters, 2010 , vol. 51, # 8 p. 1226 - 1229

93-14-1

57-13-6

70-07-5

Literature: Lunsford,C.D. et al. Journal of the American Chemical Society, 1960 , vol. 82, p. 1166 - 1171

153756-96-8

103-90-2

70-07-5

Literature: Vigroux, Alain; Bergon, Michel; Zedde, Chantal Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 3983 - 3994

Precursor 7
60420-27-1 870-63-3 124-38-9 590-28-3
93-14-1 57-13-6 153756-96-8
DownStream 3
366789-02-8 77943-39-6 104-21-2

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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