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  • Product Name: Sarsasapogenin
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126-19-2

126-19-2 structure
126-19-2 structure
  • Name: Sarsasapogenin
  • Chemical Name: (25S)-5β-spirostan-3β-ol
  • CAS Number: 126-19-2
  • Molecular Formula: C27H44O3
  • Molecular Weight: 416.637
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-02-04 08:00:00
  • Modify Date: 2024-01-03 11:14:13
  • Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities.
Name (25S)-5β-spirostan-3β-ol
Synonyms Spirostan-3-ol, (3β,5β,25S)-
PERIGENIN
5β-Spirostan-3β-ol, (25S)-
PARIGENIN
MFCD00075412
SARSAPOGENINE
EINECS 204-776-3
(2S,4aS,4bS,5'S,6aS,6bR,7S,8R,9aS,10aS,10bR,12aR)-4a,5',6a,7-Tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-8,2'-pyran]-2-ol
Sasarasapogenin
(2S,4aS,4bS,5'S,6aS,6bR,7S,8R,9aS,10aS,10bR,12aR)-4a,5',6a,7-Tétraméthyldocosahydrospiro[naphto[2',1':4,5]indéno[2,1-b]furane-8,2'-pyran]-2-ol
(3β,5β,25S)-Spirostan-3-ol
Yucca Extract
SARSAPOGENIN
(25S)-5beta-spirostan-3beta-ol
(3b,5b,25S)-Spirostan-3-ol
Yucca foam extract
sarsagenin
Sarsasapogenin
(25S)-Spirostan-3β-ol
Description Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities.
Related Catalog
Target

NF-κB

In Vitro Sarsasapogenin (20-80 μM) induces apoptosis via caspase-dependent mitochondrial pathway in heLa cells. Sarsasapogenin also induces apoptosis via the caspase-dependent mitochondrial apoptotic pathway. Sarsasapogenin (60 μM)-induced ROS generation triggers ER stress and mitochondrial dysfunction[1]. Sarsasapogenin potently inhibits NF-κB and MAPK activation, as well as IRAK1, TAK1, and IκBα phosphorylation in LPS-stimulated macrophages. Moreover, Sarsasapogenin inhibits the binding of LPS to macrophage Toll-like receptor 4, and polarization of M2 to M1 macrophages[3].
In Vivo Sarsasapogenin (20 and 40 mg/kg) significantly restores the sucrose preference deficit induced by olfactory bulbectomy (OB), and increases locomotor activity. Sarsasapogenin groups (20 and 40 mg/kg) have significantly lower immobility times, higher AChE protein expression levels than the OB group. Furthermore, Sarsasapogenin (20 and 40 mg/kg) groups have significantly higher α7-nAChR protein expression, and increases higher α4-nAChR protein expression levels compared to rats in the OB group[2]. Sarsasapogenin (5 or 10 mg/kg, p.o.) inhibits TNBS-induced colon shortening and myeloperoxidase activity in mice, reducing NF-κB activation and interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6 levels, while simultaneously increasing IL-10[3].
Cell Assay The effect of Sarsasapogenin on cell viability is measured by the MTT assay method. After exposure to Sarsasapogenin in the absence or presence of Z-VAD-FMK pretreatment for the indicated time, cells in 96-well plates are incubated with MTT. The formazan precipitate is dissolved in 200 μL of dimethyl sulfoxide, and the absorbance at 570 nm is measured using a Benchmark microplate reader.
Animal Admin The mice are randomly divided into 7 groups: normal control, TNBS-induced colitic control groups treated with vehicle, timosaponin AIII (5 or 10 mg/kg), Sarsasapogenin (5 or 10 mg/kg) or sulfasalazine (50 mg/kg). Each group consists of 6 mice. The colitis is induced by the intrarectal injection of 2.5% (w/v) TNBS solution (100 μL, dissolved in 50% ethanol) into the colon of anesthetized mice using a thin round-tip needle equipped with a syringe. The normal group is treated with vehicle alone instead of TNBS and test agents. If the injected TNBS solution is excreted, the mouse is excluded from the experiment. Timosaponin AIII or Sarsasapogenin (5 or 10 mg/kg) or sulfasalazine (50 mg/kg) dissolved in 2% tween 80 are orally administered once a day for 3 days after treatment with TNBS. The mice are killed 18 h after the final administration of test agents. The colon is quickly removed, opened longitudinally, and gently washed by PBS. Macroscopic evaluation of the colitis grade is scored (0, no ulcer and no inflammation; 1, no ulceration and local hyperemia; 2, ulceration with hyperemia; 3, ulceration and inflammation at one site only; 4, two or more sites of ulceration and inflammation; 5, ulceration extending more than 2 cm). The colons are stored at −80°C until used in the experiment for ELISA and immunoblotting.
References

[1]. Shen S, et al. Sarsasapogenin induces apoptosis via the reactive oxygen species-mediated mitochondrial pathway and ER stress pathway in HeLa cells. Biochem Biophys Res Commun. 2013 Oct 26.

[2]. Feng B, et al. Sarsasapogenin reverses depressive-like behaviors and nicotinic acetylcholine receptors induced by olfactory bulbectomy. Neurosci Lett. 2017 Feb 3;639:173-178.

[3]. Lim SM, et al. Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-κB and MAPK activation and restoring Th17/Treg cell balance. Int Immunopharmacol. 2015 Apr;25(2):493-503.
Density 1.1±0.1 g/cm3
Boiling Point 516.6±20.0 °C at 760 mmHg
Melting Point 194°C
Molecular Formula C27H44O3
Molecular Weight 416.637
Flash Point 266.2±21.8 °C
Exact Mass 416.329041
PSA 38.69000
LogP 6.21
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.552
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+
RIDADR NONH for all modes of transport
WGK Germany 3

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title: CAS No. 126-19-2 | Chemsrc address: https://www.chemsrc.com/en/baike/946587.html

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