Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Flopropione
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Flopropione
Price: ￥1608.0/50mg
Purity: 99.0%
Stocking Period: 2 Day
Contact: Liu jia

2295-58-1

2295-58-1 structure

Name: Flopropione
Chemical Name: 1-(2,4,6-trihydroxyphenyl)propan-1-one
CAS Number: 2295-58-1
Molecular Formula: C₉H₁₀O₄
Molecular Weight: 182.17300
Catalog: Chemical reagent Organic reagent Aromatic ketone
Create Date: 2018-06-18 14:09:22
Modify Date: 2024-01-02 21:00:04
Flopropione is a 5-HT1A receptor antagonist and also a catechol-o-methyltransferase (COMT) inhibitor.

Name	1-(2,4,6-trihydroxyphenyl)propan-1-one
Synonyms	Argobyl Cospanon Flopropione Phloropropiophenone Gasstenon EINECS 218-942-8 Ecapron 2',4',6'-Trihydroxypropiophenone MFCD00016456 Phlopropiophenone 1-(2,4,6-trihydroxyphenyl)-1-propanone Flopropion Chlonarin

Description	Flopropione is a 5-HT1A receptor antagonist and also a catechol-o-methyltransferase (COMT) inhibitor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> COMT Signaling Pathways >> Neuronal Signaling >> COMT Research Areas >> Neurological Disease
Target	5-HT1A receptor[1], COMT[2]
References	[1]. Aso Y et al. Relationship between the crystallization rates of amorphous nifedipine, phenobarbital, and flopropione, and their molecular mobility as measured by their enthalpy relaxation and (1)H NMR relaxation times. J Pharm Sci 89:408-16 (2000). [2]. Cospanon®. (2007).

Density	1.372g/cm3
Boiling Point	341.7ºC at 760mmHg
Melting Point	177°C
Molecular Formula	C₉H₁₀O₄
Molecular Weight	182.17300
Flash Point	174.7ºC
Exact Mass	182.05800
PSA	77.76000
LogP	1.39610
Vapour Pressure	4E-05mmHg at 25°C
Index of Refraction	1.618

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UH4429100

CHEMICAL NAME :: Propiophenone, 2',4',6'-trihydroxy-

CAS REGISTRY NUMBER :: 2295-58-1

BEILSTEIN REFERENCE NO. :: 2096799

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C9-H10-O4

MOLECULAR WEIGHT :: 182.19

WISWESSER LINE NOTATION :: 2VR BQ DQ FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 412 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 246 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 578 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 804 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	S26-S36/37/39
RTECS	UH4429100
HS Code	2914501900

108-73-6

79-03-8

~76%

2295-58-1

Literature: Mizobuchi, Shigeyuki; Sato, Yuko Agricultural and Biological Chemistry, 1985 , vol. 49, # 3 p. 719 - 724

108-73-6

2295-58-1

Literature: Organic Letters, , vol. 6, # 25 p. 4647 - 4650

108-73-6

107-12-0

2295-58-1

Literature: Journal of the Chemical Society, , p. 1255,1264 Journal of the American Chemical Society, , vol. 54, p. 2452 Journal of the South African Chemical Institute, , vol. 26, p. 41,45 Yakugaku Zasshi, , vol. 69, p. 431 Chem.Abstr., , p. 3457

17397-82-9

2295-58-1

Literature: Tetrahedron, , vol. 25, p. 707 - 714

108-73-6

123-62-6

2295-58-1

Literature: Journal of the South African Chemical Institute, , vol. 26, p. 41,45

108-73-6

802294-64-0

3145-11-7

2295-58-1

Literature: Bioscience, biotechnology, and biochemistry, , vol. 56, # 11 p. 1769 - 1772

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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