127299-95-0

127299-95-0 structure

Name: Digoxin-d3
Chemical Name: digoxin-d3
CAS Number: 127299-95-0
Molecular Formula: C₄₁H₆₁D₃O₁₄
Molecular Weight: 783.96
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-04-01 07:20:50
Modify Date: 2024-01-04 15:23:05
Digoxin-d3 is deuterium labeled Digoxin. Digoxin is a potent inhibitor of Na+/K+-ATPase, has the potential for arrhythmia and heart failure treatment.

Name	digoxin-d3

Description	Digoxin-d3 is deuterium labeled Digoxin. Digoxin is a potent inhibitor of Na+/K+-ATPase, has the potential for arrhythmia and heart failure treatment.
Related Catalog	Research Areas >> Cardiovascular Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Ashbrook AW, et al. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. MBio. 2016 May 24;7(3). pii: e00693-16.