CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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EL9154000
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CHEMICAL NAME :
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2-Butanone, 4-(methylnitrosamino)-
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CAS REGISTRY NUMBER :
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89367-15-7
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LAST UPDATED :
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199706
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DATA ITEMS CITED :
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5
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MOLECULAR FORMULA :
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C5-H10-N2-O2
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MOLECULAR WEIGHT :
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130.17
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WISWESSER LINE NOTATION :
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ONN1&2V1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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705 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Liver - other changes Kidney, Ureter, Bladder - other changes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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770 mg/kg/38W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - colon tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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1377 mg/kg/34W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
MUTATION DATA
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TYPE OF TEST :
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Mutation in mammalian somatic cells
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TEST SYSTEM :
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Rodent - hamster Lung
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DOSE/DURATION :
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700 umol/L
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REFERENCE :
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50EYAN "Structure-Activity Correlation as a Predictive Tool in Toxicology, Papers from a Symposium, 1981," Golberg, L., ed., Washington, DC, Hemisphere Pub. Corp., 1983 Volume(issue)/page/year: -,241,1983
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