410528-02-8
410528-02-8 structure
- Name: Palovarotene
- Chemical Name: 4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid
- CAS Number: 410528-02-8
- Molecular Formula: C27H30N2O2
- Molecular Weight: 414.539
- Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
- Create Date: 2018-07-08 18:10:36
- Modify Date: 2024-01-04 10:10:47
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Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.
| Name | 4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid |
|---|---|
| Synonyms |
4-{(E)-2-[5,5,8,8-Tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydro-2-naphthalenyl]vinyl}benzoic acid
Palovarotene UNII-28K6I5M16G R 667 Benzoic acid, 4-[(E)-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]- |
| Description | Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist. |
|---|---|
| Related Catalog | |
| Target |
RAR-γ[1] |
| In Vivo | Palovarotene suppresses post-traumatic chondrogenesis and osteogenesis and mitigated trauma-induced ectopic bone formation. Palovarotene inhibits subcutaneous and intramuscular heterotopic ossification (HO) in mice. Palovarotene is given orally for 14 days at 1 mg/kg/day starting on post-operative day (POD) 1 or POD-5, and HO amount, wound dehiscence and related processes are monitored for up to 84 days post injury. Compared to vehicle-control animals, Palovarotene significantly decreases HO by 50 to 60% regardless of when the treatment started and if infection is present[1]. Starting from day 1 of injury, half of the Acvr1cR206H/+ mice are treated with Palovarotene by daily gavage for 14 days and the other half received vehicle as control. Analysis by mCT and 3D image reconstruction at day 14 shows that large HO tissue masses have formed in the targeted leg of Acvr1cR206H/+ mutant mice receiving vehicle, but HO formation is greatly diminished in Palovarotene-treated companions by more than 80% based on bone volume/total volume quantification[2]. |
| Animal Admin | Rats[1] A total of 110 young adult pathogen-free male Sprague Dawley rats (Rattus norvegicus; 400-600 g) are used. Rats receive via oral gavage (100 μL) either Palovarotene (1.0 mg/kg) or vehicle as control (5% DMSO in corn oil) prepared every other day for 14 days, starting at postoperative day 1 (POD-1) or POD-5. Rats are euthanized at indicated time points post-injury for ex vivo end point analysis by micro-computed CT (μCT), histology and RT-PCR gene transcript expression. Mice[2] One-month-old Acvr1cR206H/+ mice are provided doxycycline chow for 3 days to induce mutant gene expression globally. Mouse quadriceps muscles are injured by injection with 50 mL of 10mM cardiotoxin. Beginning on the day of injury, Palovarotene or vehicle (1:4 DMSO in corn oil) is administered daily for 14 days by oral gavage (100 mg/mouse from days 1 to 3 and 15mg/mouse from days 4 to 14) using a 20-gauge gavage needle. Palovarotene solution in DMSO is stored at -20°C under argon and diluted (1:4) with corn oil for administration. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 592.3±50.0 °C at 760 mmHg |
| Molecular Formula | C27H30N2O2 |
| Molecular Weight | 414.539 |
| Flash Point | 312.0±30.1 °C |
| Exact Mass | 414.230713 |
| PSA | 55.12000 |
| LogP | 7.63 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.595 |
| Storage condition | 2-8℃ |