324758-66-9

324758-66-9 structure

Name: Sabiporide hydrochloride
Chemical Name: N-(diaminomethylidene)-4-[4-(1H-pyrrole-2-carbonyl)piperazin-1-yl]-3-(trifluoromethyl)benzamide
CAS Number: 324758-66-9
Molecular Formula: C₁₈H₁₉F₃N₆O₂
Molecular Weight: 408.37800
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-04-01 01:12:29
Modify Date: 2024-02-08 11:14:42
Sabiporide hydrochloride is a NHE-1 inhibitor (Ki: 50 nM). Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death[1][2].

Name	N-(diaminomethylidene)-4-[4-(1H-pyrrole-2-carbonyl)piperazin-1-yl]-3-(trifluoromethyl)benzamide
Synonyms	Sabiporide UNII-U52APA00X7 Sabiporide HCl

Description	Sabiporide hydrochloride is a NHE-1 inhibitor (Ki: 50 nM). Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease
References	[1]. Touret N, et al. Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects. Eur J Pharmacol. 2003 Jan 17;459(2-3):151-8. [2]. Park HS, et al. Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia. Brain Res. 2005 Nov 2;1061(1):67-71.