485842-97-5

485842-97-5 structure

Name: PMX464
Chemical Name: 4-(1,3-benzothiazol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-one
CAS Number: 485842-97-5
Molecular Formula: C₁₃H₉NO₂S
Molecular Weight: 243.28
Catalog: Research Areas Cancer
Create Date: 2016-02-12 01:28:49
Modify Date: 2024-01-09 10:16:47
PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells[1].

Name	4-(1,3-benzothiazol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-one
Synonyms	UNII-YJX11V636Q PMX-464 AW-464 Threo-methylphenidate hydrochloride

Description	PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Callister ME, et, al. PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells. Br J Pharmacol. 2008 Nov;155(5):661-72.

Molecular Formula	C₁₃H₉NO₂S
Molecular Weight	243.28
Exact Mass	243.03500
PSA	78.43000
LogP	2.17900

6265-55-0

~53%

485842-97-5

Literature: Wells, Geoffrey; Berry, Jane M.; Bradshaw, Tracey D.; Burger, Angelika M.; Seaton, Angela; Wang, Bo; Westwell, Andrew D.; Stevens, Malcolm F. G. Journal of Medicinal Chemistry, 2003 , vol. 46, # 4 p. 532 - 541

95-16-9

485842-97-5

1192371-77-9

485842-97-5

Literature: Chakraborty, Mrinal; Jin, Kyoung Joo; Glover, Stephen A.; Novak, Michael Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5296 - 5304

Precursor 2
6265-55-0 95-16-9
DownStream 1
934-34-9

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