Cyclamic acid

Modify Date: 2024-01-03 10:02:35

Cyclamic acid Structure
Cyclamic acid structure
 Common Name Cyclamic acid
CAS Number 100-88-9 Molecular Weight 179.23700
Density 1.32g/cm3 Boiling Point N/A
Molecular Formula C6H13NO3S Melting Point ~180 °C (dec.)
MSDS USA Flash Point N/A

 Use of Cyclamic acid


Cyclamic acid is one of the most widely used artificial sweeteners.Target: OthersCyclamic acid in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners in food and pharmaceuticals. Cyclamic acid is in use in more than 50 countries, especially in combination with other sweeteners, to eliminate aftertaste. Wikipedia.

 Names

Name cyclohexylsulfamic acid
Synonym More Synonyms

 Cyclamic acid Biological Activity

Description Cyclamic acid is one of the most widely used artificial sweeteners.Target: OthersCyclamic acid in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners in food and pharmaceuticals. Cyclamic acid is in use in more than 50 countries, especially in combination with other sweeteners, to eliminate aftertaste. Wikipedia.
Related Catalog
References

[1]. http://en.wikipedia.org/wiki/Cyclamic_acid

 Chemical & Physical Properties

Density 1.32g/cm3
Melting Point ~180 °C (dec.)
Molecular Formula C6H13NO3S
Molecular Weight 179.23700
Exact Mass 179.06200
PSA 74.78000
LogP 2.18320
Index of Refraction 1.529
Storage condition Refrigerator

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GV6950000
CHEMICAL NAME :
Cyclohexanesulfamic acid
CAS REGISTRY NUMBER :
100-88-9
BEILSTEIN REFERENCE NO. :
2208885
LAST UPDATED :
199710
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C6-H13-N-O3-S
MOLECULAR WEIGHT :
179.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841- Volume(issue)/page/year: 225,551,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841- Volume(issue)/page/year: 225,551,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841- Volume(issue)/page/year: 225,551,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01774 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
22 gm/kg/77W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - tumors
REFERENCE :
JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 118,258,1977
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
131 gm/kg/5Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
REFERENCE :
JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 118,258,1977
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
164 gm/kg/6Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - hematuria Kidney, Ureter, Bladder - tumors
REFERENCE :
JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1917- Volume(issue)/page/year: 118,258,1977

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS GV6950000
HS Code 2935009090

 Synthetic Route

Cyclohexylamine structure

Cyclohexylamine

CAS#:108-91-8

~69%

Cyclamic acid Structure

Cyclamic acid

CAS#:100-88-9

Literature: White, Emil H.; Li, Min; Lu, Shanzheng Journal of Organic Chemistry, 1992 , vol. 57, # 4 p. 1252 - 1258
Nitrocyclohexane structure

Nitrocyclohexane

CAS#:1122-60-7

~%

Cyclamic acid Structure

Cyclamic acid

CAS#:100-88-9

Literature: Journal of Organic Chemistry, , vol. 9, p. 89,94
N-Cyclohexylhydroxylamine structure

N-Cyclohexylhyd...

CAS#:2211-64-5

~%

Cyclamic acid Structure

Cyclamic acid

CAS#:100-88-9

Literature: US2850531 , ; DE950369 , ;
cyclohexylisocyanate structure

cyclohexylisocyanate

CAS#:3173-53-3

~%

Cyclamic acid Structure

Cyclamic acid

CAS#:100-88-9

Literature: US2800501 , ;

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Articles2

More Articles
Identification of sulfation sites of metabolites and prediction of the compounds' biological effects.

Anal. Bioanal. Chem 386(3) , 666-74, (2006)

Characterizing the biological effects of metabolic transformations (or biotransformation) is one of the key steps in developing safe and effective pharmaceuticals. Sulfate conjugation, one of the majo...

Modification of physical properties of certain antitussive and antihistaminic agents by formation of N-cyclohexylsulfamate salts.

J. Pharm. Sci. 51 , 931-4, (1962)

 Synonyms

Cyclamic acid
MFCD00065234
Cyclohexylsulfamic acid
N-Cyclohexylsulfamic Acid
EINECS 202-898-1
Cyclohexanesulfamic Acid
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Chemsrc provides Cyclamic acid(CAS#:100-88-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Cyclamic acid are included as well.>> amp version: Cyclamic acid

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