FFN511
Modify Date: 2024-01-13 15:42:42
FFN511 structure
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Common Name | FFN511 | ||
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| CAS Number | 1004548-96-2 | Molecular Weight | 284.353 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 538.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C17H20N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 279.5±30.1 °C | |
Use of FFN511FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices[1][2]. |
| Name | 9-(2-Aminoethyl)-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11-one |
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| Synonym | More Synonyms |
| Description | FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices[1][2]. |
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| Related Catalog | |
| In Vitro | FFN511 (350 nM; 30 min) accumulats in a pattern consistent with LDCVs in cultured mouse chromaffin cells, and the accumulation is abolished by the lipophilic base chloroquine[1]. Cell Viability Assay[1] Cell Line: mouse chromaffin cells Concentration: 350 nM Incubation Time: 30 min Result: Accumulated in cultured mouse chromaffin cells (the same as LDCVs), and the accumulation could be abolished by the lipophilic base chloroquine, which collapses the vesicle pH gradient. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 538.5±50.0 °C at 760 mmHg |
| Molecular Formula | C17H20N2O2 |
| Molecular Weight | 284.353 |
| Flash Point | 279.5±30.1 °C |
| Exact Mass | 284.152466 |
| LogP | 3.05 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.658 |
| 1H,5H,11H-[1]Benzopyrano[6,7,8-ij]quinolizin-11-one, 9-(2-aminoethyl)-2,3,6,7-tetrahydro- |
| 9-(2-Aminoethyl)-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11-one |