CV-6209
CV-6209 structure
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Common Name | CV-6209 | ||
|---|---|---|---|---|
| CAS Number | 100488-87-7 | Molecular Weight | 642.31 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H60ClN3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CV-6209CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC50s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats[1]. |
| Name | 2-<propoxy>carbonyl>amino>methyl>-1-ethylpyridinium chloride |
|---|---|
| Synonym | More Synonyms |
| Description | CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC50s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats[1]. |
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| Related Catalog | |
| Target |
platelet activating factor (PAF)[1] |
| In Vitro | CV-6209 inhibits [3H]serotonin release from rabbit platelets stimulated with PAF (30 nM)[1]. CV-6209 has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen[1]. CV-6209 (0.2-2 μM; pretreated for 30 min) inhibits PAF-induced MC degranulation in both LAD2 and hLMCs[1]. |
| In Vivo | CV-6209 (i.v.) inhibits PAF (0.3 μg/kg; i.v.)-induced hypotension in rats (ED50=0.009 mg/kg) with no effect on the hypotension induced by arachidonic acid, histamine, bradykinin and isoproterenol[1]. CV-6209 (66 μg; i.v.) reduces asparaginase-induced hypersensitivity compared with nonpretreated, sensitized mice[3]. |
| References |
| Molecular Formula | C34H60ClN3O6 |
|---|---|
| Molecular Weight | 642.31 |
| Exact Mass | 641.41700 |
| PSA | 98.05000 |
| LogP | 8.67470 |
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CV-6209 CAS#:100488-87-7 |
| Literature: Journal of Medicinal Chemistry, , vol. 32, # 1 p. 56 - 64 |
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CV-6209 CAS#:100488-87-7 |
| Literature: Journal of Medicinal Chemistry, , vol. 32, # 1 p. 56 - 64 |
|
~%
CV-6209 CAS#:100488-87-7 |
| Literature: Journal of Medicinal Chemistry, , vol. 32, # 1 p. 56 - 64 |
|
~%
CV-6209 CAS#:100488-87-7 |
| Literature: Journal of Medicinal Chemistry, , vol. 32, # 1 p. 56 - 64 |
|
~%
CV-6209 CAS#:100488-87-7 |
| Literature: Journal of Medicinal Chemistry, , vol. 32, # 1 p. 56 - 64 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |
| 2-{N-acetyl-N-[({2-methoxy-3-[(octadecylcarbamoyl)oxy]propoxy}carbonyl)amino]methyl}-1-ethylpyridinium chloride |
| 2-{N-[1-(3,4-dihydroxyphenyl)ethyl]amino}acetaldehyde dimethyl acetal hydrochloride |
| 1,2-Benzenediol,4-[1-[(2,2-dimethoxyethyl)amino]ethyl]-,hydrochloride |
| 2-(2-ACETYL-6-METHOXY-3,9-DIOXO-4,8-DIOXA-2,10-DIAZAOCTACOS-1-YL)-1-ETHYL-PYRIDINIUM CHLORIDE |