N-Acetyl-3-acetoxy-5-phenylpyrrole

Modify Date: 2024-01-10 17:49:25

N-Acetyl-3-acetoxy-5-phenylpyrrole Structure
N-Acetyl-3-acetoxy-5-phenylpyrrole structure
Common Name N-Acetyl-3-acetoxy-5-phenylpyrrole
CAS Number 100750-39-8 Molecular Weight 243.25800
Density N/A Boiling Point N/A
Molecular Formula C14H13NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N-Acetyl-3-acetoxy-5-phenylpyrrole


APPA is an aldose reductase inhibitor. APPA can effectively prevent apoptosis and the symptoms of Streptozotocin (HY-13753)-induced diabetes by inhibiting the polyol pathway in rats. APPA has the potential for diabetic nephropathy (DN) research[1].

 Names

Name (1-acetyl-5-phenylpyrrol-3-yl) acetate
Synonym More Synonyms

 N-Acetyl-3-acetoxy-5-phenylpyrrole Biological Activity

Description APPA is an aldose reductase inhibitor. APPA can effectively prevent apoptosis and the symptoms of Streptozotocin (HY-13753)-induced diabetes by inhibiting the polyol pathway in rats. APPA has the potential for diabetic nephropathy (DN) research[1].
Related Catalog
References

[1]. Zhi-Ming Xiu, et al. 1-Acetyl-5-phenyl-1H-pyrrol-3-ylacetate: An aldose reductase inhibitor for the treatment of diabetic nephropathy. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4482-4487.  

 Chemical & Physical Properties

Molecular Formula C14H13NO3
Molecular Weight 243.25800
Exact Mass 243.09000
PSA 48.30000
LogP 2.74050

 Synthetic Route

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N-Acetyl-3-acetoxy-5-phenylpyrrole Structure

N-Acetyl-3-acet...

CAS#:100750-39-8

Literature: Chemische Berichte, , vol. 63, p. 2870,2874

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N-Acetyl-3-acetoxy-5-phenylpyrrole Structure

N-Acetyl-3-acet...

CAS#:100750-39-8

Literature: Chemische Berichte, , vol. 63, p. 2870,2874

~%

N-Acetyl-3-acetoxy-5-phenylpyrrole Structure

N-Acetyl-3-acet...

CAS#:100750-39-8

Literature: Chemische Berichte, , vol. 63, p. 2870,2874

 Synonyms

N-ACETYL-3-ACETOXY-5-PHENYLPYRROLE
1-Acetyl-5-phenyl-1H-pyrrol-3-ol Acetate
4-acetoxy-1-acetyl-2-phenyl-pyrrole
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