Piceatannol

Modify Date: 2024-01-03 18:25:49

Piceatannol Structure
Piceatannol structure
 Common Name Piceatannol
CAS Number 10083-24-6 Molecular Weight 244.243
Density 1.5±0.1 g/cm3 Boiling Point 507.3±38.0 °C at 760 mmHg
Molecular Formula C14H12O4 Melting Point 223-227ºC
MSDS Chinese USA Flash Point 252.2±21.4 °C

 Use of Piceatannol


Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]

 Names

Name Piceatannol
Synonym More Synonyms

 Piceatannol Biological Activity

Description Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]
Related Catalog
References

[1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7.

[2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 507.3±38.0 °C at 760 mmHg
Melting Point 223-227ºC
Molecular Formula C14H12O4
Molecular Weight 244.243
Flash Point 252.2±21.4 °C
Exact Mass 244.073563
PSA 80.92000
LogP 2.69
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.801
Storage condition 2-8°C
Water Solubility H2O: 0.5 mg/mL

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2907299090

 Customs

HS Code 2907299090
Summary 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

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 Synonyms

3,3',4'5-Tetrahydroxystilbene
E-Piceatannol
1,2-Benzenediol, 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]-
3,3′,4,5′-Tetrahydroxy-trans-stilbene
3,3',4,5'-Tetrahydroxy-trans-stilbene
3,4,3',5'-Tetrahydroxy-trans-stilbene
4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]benzene-1,2-diol
3,5,3',4'-tetrahydroxystilbene
4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-1,2-benzenediol
Piceatannol
4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
MFCD00221715
4-(2-(3,5-Dihydroxyphenyl)vinyl)-1,2-benzenediol
(E)-4-[2-(3,5Dihydroxyphenyl)ethenyl]1,2-benzenediol
(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol
5-[(E)-2-(3,4-Dihydroxyphenyl)vinyl]benzene-1,3-diol
trans-3,3',4,5'-tetrahydroxystilbene
3,3',4,5'-tetrahydroxystilbene
Piceatannol, (E)-
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(E)-piceatannol
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cis-Piceatannol
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piceatannol 3-O-β-D-(6''-O-galloyl) glucopyranoside
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1-(4-Amino-2-bromophenyl)azetidine-2-carboxamide
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Chemsrc provides Piceatannol(CAS#:10083-24-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Piceatannol are included as well.>> amp version: Piceatannol

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