NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE

Modify Date: 2024-01-08 11:01:07

NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE Structure
NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE structure
Common Name NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE
CAS Number 100900-19-4 Molecular Weight 679.76600
Density N/A Boiling Point N/A
Molecular Formula C33H45N9O7 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS08
GHS08
Signal Word Warning

 Use of NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE


Z-Arg-Arg-4MβNA triacetate is a cathepsin B-specific substrate and can produce fluorescent end product 4MβNA (λex = 355 nm, λem = 430 nm)[1][2].

 Names

Name acetic acid,benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methoxynaphthalen-2-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Synonym More Synonyms

 NA-CBZ-ARG-ARG 4-METHOXY-B-NAPHTHYLAMIDE Biological Activity

Description Z-Arg-Arg-4MβNA triacetate is a cathepsin B-specific substrate and can produce fluorescent end product 4MβNA (λex = 355 nm, λem = 430 nm)[1][2].
Related Catalog
Target

Cathepsin B

References

[1]. Büth H, et al. HaCaT keratinocytes secrete lysosomal cysteine proteinases during migration. Eur J Cell Biol. 2004 Dec;83(11-12):781-95.

[2]. van den Bos T, et al. Differences in matrix composition between calvaria and long bone in mice suggest differences in biomechanical properties and resorption: Special emphasis on collagen. Bone. 2008 Sep;43(3):459-68.

 Chemical & Physical Properties

Molecular Formula C33H45N9O7
Molecular Weight 679.76600
Exact Mass 679.34400
PSA 277.33000
LogP 6.26020

 Safety Information

Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H351
Precautionary Statements P281
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn: Harmful;
Risk Phrases 40
Safety Phrases 22-36
RIDADR NONH for all modes of transport

 Articles2

More Articles
A simple, economical method for staining gels for cathepsin B-like activity.

Anal. Biochem. 119 , 148, (1982)

In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption.

Biochem. Biophys. Res. Commun. 125 , 441, (1984)

The excretion of cathepsin B, a lysosomal cysteine proteinase, by parathyroid hormone-stimulated embryonic mouse calvaria in culture, correlates closely with the extent of bone resorption evaluated by...

 Synonyms

Z-Arg-Arg 4-methoxy-|A-naphthylamide acetate salt
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