Lapatinib-d7 ditosylate

Modify Date: 2024-01-12 22:19:13

Lapatinib-d7 ditosylate structure	Common Name	Lapatinib-d7 ditosylate
	CAS Number	1009307-24-7	Molecular Weight	753.25900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₃₄ClFN₄O₇S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Lapatinib-d7 ditosylate

Lapatinib-d7 (GW572016-d7) ditosylate is the deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1][2].

Name	N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[1,1,2,2-tetradeuterio-2-(trideuteriomethylsulfonyl)ethyl]amino]methyl]furan-2-yl]quinazolin-4-amine,4-methylbenzenesulfonic acid
Synonym	More Synonyms

Description	Lapatinib-d7 (GW572016-d7) ditosylate is the deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Apoptosis >> Ferroptosis Signaling Pathways >> Autophagy >> Autophagy
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94

Molecular Formula	C₃₆H₃₄ClFN₄O₇S₂
Molecular Weight	753.25900
Exact Mass	752.15400
PSA	177.48000
LogP	10.00630

N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl-d7]amino]methyl]-2-furanyl]-4-quinazolinamine Bis(4-methylbenzenesulfonate) Ditosylate

Tykerb-d7 Ditosylate

Lapatinib-d7 Ditosylate

Lapatinib-d7 ditosylate

Use of Lapatinib-d7 ditosylate

Names

Lapatinib-d7 ditosylate Biological Activity

Chemical & Physical Properties

Synonyms