holocalin(p)

Modify Date: 2024-01-08 11:26:43

holocalin(p) Structure
holocalin(p) structure
 Common Name holocalin(p)
CAS Number 101-93-9 Molecular Weight 298.37900
Density 1.04g/cm3 Boiling Point 464.5ºC at 760mmHg
Molecular Formula C18H22N2O2 Melting Point 117°C
MSDS N/A Flash Point 234.7ºC

 Use of holocalin(p)


Phenacaine (Holocaine) is a local anesthetic. Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca2+-ATPase and cyclic nucleotide phosphodiesterases from brain and heart[1][2].

 Names

Name N,N'-bis(4-ethoxyphenyl)ethanimidamide
Synonym More Synonyms

 holocalin(p) Biological Activity

Description Phenacaine (Holocaine) is a local anesthetic. Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca2+-ATPase and cyclic nucleotide phosphodiesterases from brain and heart[1][2].
Related Catalog
In Vitro Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca2+-ATPase (EC 3.6.1.3) and cyclic nucleotide phosphodiesterase (EC 3.1.4.17) in brain and heart tissues[1]. Phenacaine (1 μM-1 mM) depresses glucose-induced insulin secretion by pancreas[2].

 Chemical & Physical Properties

Density 1.04g/cm3
Boiling Point 464.5ºC at 760mmHg
Melting Point 117°C
Molecular Formula C18H22N2O2
Molecular Weight 298.37900
Flash Point 234.7ºC
Exact Mass 298.16800
PSA 42.85000
LogP 4.71900
Vapour Pressure 8.29E-09mmHg at 25°C
Index of Refraction 1.534

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AD0350000
CHEMICAL NAME :
Acetamidine, N,N'-bis(p-ethoxyphenyl)-
CAS REGISTRY NUMBER :
101-93-9
BEILSTEIN REFERENCE NO. :
2702842
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C18-H22-N2-O2
MOLECULAR WEIGHT :
298.42
WISWESSER LINE NOTATION :
2OR DNUY1&MR DO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
53 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932

 Safety Information

HS Code 2925290090

 Synthetic Route

 Customs

HS Code 2925290090
Summary 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Synonyms

Fenacaine
Holocaine
Phenacaine
Tanicaine
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