Curvularin

Modify Date: 2024-01-12 11:18:30

Curvularin Structure
Curvularin structure
Common Name Curvularin
CAS Number 10140-70-2 Molecular Weight 292.32700
Density 1.2g/cm3 Boiling Point 557ºC at 760mmHg
Molecular Formula C16H20O5 Melting Point 205-207 °C
MSDS Chinese USA Flash Point 207.9ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Curvularin


Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2].

 Names

Name 2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-, (-)
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2g/cm3
Boiling Point 557ºC at 760mmHg
Melting Point 205-207 °C
Molecular Formula C16H20O5
Molecular Weight 292.32700
Flash Point 207.9ºC
Exact Mass 292.13100
PSA 83.83000
LogP 2.71880
Vapour Pressure 5.18E-13mmHg at 25°C
Index of Refraction 1.54

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xn
RIDADR NONH for all modes of transport

 Articles15

More Articles
Sulfur-containing cytotoxic curvularin macrolides from Penicillium sumatrense MA-92, a fungus obtained from the rhizosphere of the mangrove Lumnitzera racemosa.

J. Nat. Prod. 76(11) , 2145-9, (2013)

Sumalarins A-C (1-3), the new and rare examples of sulfur-containing curvularin derivatives, along with three known analogues (4-6), were isolated and identified from the cytotoxic extract of Penicill...

Metabolite production by differentUlocladiumspecies

Int. J. Food Microbiol. 126(1-2) , 172-9, (2008)

Ulocladium, which is phylogenetically related to Alternaria, contains species that are food spoilers and plant pathogens, but also species that have potential as enzyme producers and bio-control agent...

[Molecular basis of probes for cytoskeletal proteins].

Tanpakushitsu Kakusan Koso. 38(11) , 1730-41, (1993)

 Synonyms

curvularin