mAChR antagonist 1

Modify Date: 2024-01-11 16:21:27

mAChR antagonist 1 Structure
mAChR antagonist 1 structure
Common Name mAChR antagonist 1
CAS Number 101491-79-6 Molecular Weight 310.39000
Density 1.18g/cm3 Boiling Point 437ºC at 760 mmHg
Molecular Formula C19H22N2O2 Melting Point N/A
MSDS N/A Flash Point 218.1ºC

 Use of mAChR antagonist 1


mAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively[1].

 Names

Name (1-methylpiperidin-4-yl) N,N-diphenylcarbamate
Synonym More Synonyms

 mAChR antagonist 1 Biological Activity

Description mAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively[1].
Related Catalog
Target

mAChR1:255 nM (Ki)

mAChR3:121 nM (Ki)

mAChR4:158 nM (Ki)

mAChR5:255 nM (Ki)

mAChR2:>1000 nM (Ki)

References

[1]. Marlon Millard, et al. Design, synthesis and preclinical evaluation of muscarine receptor antagonists via a scaffold-hopping approach. Eur J Med Chem. 2023 Oct 21:262:115891.  

 Chemical & Physical Properties

Density 1.18g/cm3
Boiling Point 437ºC at 760 mmHg
Molecular Formula C19H22N2O2
Molecular Weight 310.39000
Flash Point 218.1ºC
Exact Mass 310.16800
PSA 32.78000
LogP 3.99340
Vapour Pressure 7.74E-08mmHg at 25°C
Index of Refraction 1.613

 Synonyms

1-Methyl-4-piperidyl diphenylcarbamate
1-methylpiperidin-4-yl diphenylcarbamate
CARBAMIC ACID,DIPHENYL-,1-METHYL-4-PIPERIDYL ESTER