Protosappanin B

Modify Date: 2024-01-02 18:49:10

Protosappanin B Structure
Protosappanin B structure
Common Name Protosappanin B
CAS Number 102036-29-3 Molecular Weight 304.29
Density 1.5±0.1 g/cm3 Boiling Point 655.5±55.0 °C at 760 mmHg
Molecular Formula C16H16O6 Melting Point N/A
MSDS N/A Flash Point 350.2±31.5 °C

 Use of Protosappanin B


Protosappanin B is a phenolic compound extracted from Lignum Sappan. Anti-cancer activity[1]. Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells[2].

 Names

Name Protosappanin B
Synonym More Synonyms

 Protosappanin B Biological Activity

Description Protosappanin B is a phenolic compound extracted from Lignum Sappan. Anti-cancer activity[1]. Protosappanin B induces apoptosis and causes G1 cell cycle arrest in human bladder cancer cells[2].
Related Catalog
Target

Apoptosis[2]

In Vitro Protosappanin B (12.5, 25, 50, 100, 200 µg/mL, 48 hours) dose-dependently inhibits tumor cells, with IC50s of 21.32 µg/mL, 26.73 µg/mL, and 76.53 µg/mL for SW-480, HCT-116, and BTT cells, respectively[1]. Cell Viability Assay[1] Cell Line: CT-116, SW-480, and BTT Cells Concentration: 12.5, 25, 50, 100, 200 µg/mL Incubation Time: 48 hours Result: Dose-dependently inhibited tumor cells after 48 hours of treatment.
References

[1]. Yang X, et al. Antitumor Effects of Purified Protosappanin B Extracted From Lignum Sappan. Integr Cancer Ther. 2016 Mar;15(1):87-95.

[2]. Yang X, et al. Protosappanin B promotes apoptosis and causes G1 cell cycle arrest in human bladder cancer cells. Sci Rep. 2019 Jan 31;9(1):1048.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 655.5±55.0 °C at 760 mmHg
Molecular Formula C16H16O6
Molecular Weight 304.29
Flash Point 350.2±31.5 °C
Exact Mass 304.094696
PSA 110.38000
LogP 1.13
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.700
Storage condition 2~8℃

 Safety Information

Hazard Codes Xi

 Synthetic Route

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Protosappanin B Structure

Protosappanin B

CAS#:102036-29-3

Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 6 p. 1490 - 1494

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Protosappanin B Structure

Protosappanin B

CAS#:102036-29-3

Literature: Chemical & Pharmaceutical Bulletin, , vol. 35, # 7 p. 3002 - 3005

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

(7S)-7-(Hydroxymethyl)-7,8-dihydro-6H-dibenzo[b,d]oxocine-3,7,10,11-tetrol
6H-Dibenz[b,d]oxocin-3,7,10,11-tetrol, 7,8-dihydro-7-(hydroxymethyl)-, (7S)-
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