MK-1
Modify Date: 2024-07-21 10:30:51
MK-1 structure
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Common Name | MK-1 | ||
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| CAS Number | 1026307-65-2 | Molecular Weight | 573.58 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H26F3N7O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MK-1MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation; a PDGFR inhibitor that inhibits PDGF-CC-mediated PDGFR phosphorylation in U138-malignant glioma cells, also inhibits the PDGF-CC-induced phosphorylation of PLCγ1, a major downstream target of PDGFR. |
| Name | MK-1 |
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| Description | MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation; a PDGFR inhibitor that inhibits PDGF-CC-mediated PDGFR phosphorylation in U138-malignant glioma cells, also inhibits the PDGF-CC-induced phosphorylation of PLCγ1, a major downstream target of PDGFR. |
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| References | References 1. Boitano AE, et al. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14019-23. View Related Products by Target PDGFR |
| Molecular Formula | C30H26F3N7O2 |
|---|---|
| Molecular Weight | 573.58 |