L-364373

Modify Date: 2024-01-09 15:49:27

L-364373 structure	Common Name	L-364373
	CAS Number	103342-82-1	Molecular Weight	397.44400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₀FN₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of L-364373

L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes[1].

Name	(3R)-5-(2-fluorophenyl)-3-(1H-indol-3-ylmethyl)-1-methyl-3H-1,4-benzodiazepin-2-one
Synonym	More Synonyms

Description	L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Jow F, et al. Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev Technol. 2006 Aug;4(4):443-50.