(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) trifluoroacetate salt

Modify Date: 2024-01-03 10:46:50

(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) trifluoroacetate salt structure	Common Name	(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) trifluoroacetate salt
	CAS Number	103613-84-9	Molecular Weight	1036.273
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₅₀H₈₁N₁₅O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) trifluoroacetate salt

(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) (E-2078), a stable Dynorphin A (1–8) (HY-P2159) analog, is a kappa opioid receptor (KOR) agonist[1].

Name	(2R)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]pentanoyl]-met
Synonym	More Synonyms

Description	(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) (E-2078), a stable Dynorphin A (1–8) (HY-P2159) analog, is a kappa opioid receptor (KOR) agonist[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	κ Opioid Receptor/KOR
References	[1]. Butelman ER, et al. Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys. Psychopharmacology (Berl). 1999 Nov;147(1):73-80.

Density	1.3±0.1 g/cm3
Molecular Formula	C₅₀H₈₁N₁₅O₉
Molecular Weight	1036.273
Exact Mass	1035.634155
PSA	404.50000
LogP	1.86
Index of Refraction	1.616

H-MeTyr-Gly-Gly-Phe-Leu-Arg-MeArg-D-Leu-NHEt

D-Leucinamide, N-methyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N-(diaminomethylene)-L-ornithyl-N-(diaminomethylene)-N-methyl-L-ornithyl-N-ethyl-

N-Methyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N-(diaminomethylene)-L-ornithyl-N-(diaminomethylene)-N-methyl-L-ornithyl-N-ethyl-D-leucinamide

N-Me-Tyr-gly-gly-phe-leu-arg-N-Me-arg-leu-NH-C2H5

N-Methyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginyl-N-methyl-arginyl-leucyl ethylamide

E-2078

D-Leucinamide,N-methyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-N2-methyl-L-arginyl-N-ethyl

C50H81N15O9

MeTyr-Gly-Gly-Phe-Leu-Arg-MeArg-D-Leu-NHEt

(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) trifluoroacetate salt

Use of (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) trifluoroacetate salt

Names

Biological Activity

Chemical & Physical Properties

Synonyms