Gimeracil
Gimeracil structure
|
Common Name | Gimeracil | ||
|---|---|---|---|---|
| CAS Number | 103766-25-2 | Molecular Weight | 145.544 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 524.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C5H4ClNO2 | Melting Point | 274 °C | |
| MSDS | N/A | Flash Point | 270.8±28.7 °C | |
Use of GimeracilGimeracil(Gimestat) is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood; inhibits homologous recombination.IC50 Value: Target: DPYDin vitro: Gimeracil had radiosensitizing effects by partially inhibiting homologous recombination (HR) in the repair of DNA double strand breaks. Tail moments in neutral comet assay increased in gimeracil-treated cells. Gimeracil restrained the formation of foci of Rad51 and replication protein A (RPA), whereas it increased the number of foci of Nbs1, Mre11, Rad50, and FancD2. Gimeracil did not sensitize DPYD-depleted cells [1]. Gimeracil inhibited DNA DSB repair. It did not sensitize cells deficient in HR but sensitized those deficient in NHEJ. In SCneo assay, Gimeracil reduced the frequency of neo-positive clones. Additionally, it sensitized the cells in S-phase more than in G0/G1 [2].in vivo: |
| Name | 5-chloro-4-hydroxy-1H-pyridin-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | Gimeracil(Gimestat) is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood; inhibits homologous recombination.IC50 Value: Target: DPYDin vitro: Gimeracil had radiosensitizing effects by partially inhibiting homologous recombination (HR) in the repair of DNA double strand breaks. Tail moments in neutral comet assay increased in gimeracil-treated cells. Gimeracil restrained the formation of foci of Rad51 and replication protein A (RPA), whereas it increased the number of foci of Nbs1, Mre11, Rad50, and FancD2. Gimeracil did not sensitize DPYD-depleted cells [1]. Gimeracil inhibited DNA DSB repair. It did not sensitize cells deficient in HR but sensitized those deficient in NHEJ. In SCneo assay, Gimeracil reduced the frequency of neo-positive clones. Additionally, it sensitized the cells in S-phase more than in G0/G1 [2].in vivo: |
|---|---|
| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 524.2±45.0 °C at 760 mmHg |
| Melting Point | 274 °C |
| Molecular Formula | C5H4ClNO2 |
| Molecular Weight | 145.544 |
| Flash Point | 270.8±28.7 °C |
| Exact Mass | 144.993057 |
| PSA | 53.09000 |
| LogP | -1.50 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.641 |
| Storage condition | Refrigerator |
| Hazard Codes | F,C |
|---|---|
| Risk Phrases | R11:Highly Flammable. R14:Reacts violently with water. R34:Causes burns. |
| Safety Phrases | S16-S26-S33-S36/37/39-S45 |
| RIDADR | UN 2985 3/PG 2 |
| WGK Germany | 1 |
| Packaging Group | II |
| Hazard Class | 3 |
| HS Code | 2942000000 |
|
~71%
Gimeracil CAS#:103766-25-2 |
| Literature: TAIHO PHARMACEUTICAL COMPANY LIMITED Patent: EP1842847 A1, 2007 ; Location in patent: Page/Page column 10 ; |
|
~33%
Gimeracil CAS#:103766-25-2 |
| Literature: TAIHO PHARMACEUTICAL COMPANY LIMITED Patent: EP1842847 A1, 2007 ; Location in patent: Page/Page column 9-10 ; |
|
~%
Gimeracil CAS#:103766-25-2 |
| Literature: EP1842847 A1, ; Page/Page column 9 ; |
|
~%
Gimeracil CAS#:103766-25-2 |
| Literature: Recueil des Travaux Chimiques des Pays-Bas, 73<1954<704,708 |
|
~%
Gimeracil CAS#:103766-25-2 |
| Literature: Recueil des Travaux Chimiques des Pays-Bas, , vol. 72, p. 285,291 |
|
~%
Gimeracil CAS#:103766-25-2 |
| Literature: Recueil des Travaux Chimiques des Pays-Bas, , vol. 72, p. 285,291 |
|
~%
Gimeracil CAS#:103766-25-2 |
| Literature: Recueil des Travaux Chimiques des Pays-Bas, , vol. 72, p. 285,291 |
![3-chloro-1,5-dioxaspiro[5.5]undec-3-en-2-one structure](https://image.chemsrc.com/caspic/115/134878-51-6.png)
| Precursor 5 | |
|---|---|
| DownStream 5 | |
CAS#:405230-82-2
CAS#:103766-97-8
CAS#:155131-51-4
CAS#:103815-09-4
CAS#:55934-01-5| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 1,2-Dihydro-5-chloro-4-hydroxybenzene |
| 5-Chloro-4-hydroxy-2(1H)-pyridinone |
| 2(1H)-Pyridinone, 5-chloro-4-hydroxy- |
| 5-chloropyridine-2,4-diol |
| Gimeracil |
| 2,4-dihydroxy-5-chloropyridine |
| 5-Chloro-2,4-pyridinediol |
| 5-Chloro-2,4-dihydroxypyridine |
| 5-Chlor-pyridin-2,4-diol |
| 5-Chloro-4-hydroxypyridin-2(1H)-one |
| MFCD08458352 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Gimeracil
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Gimeracil
- Price: ￥658.0/25g ￥198.0/5g
- Purity: 99.0%
- Delivery: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Gimeracil
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: Gimeracil
- Price: $300.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: 5-chloro-4-hydroxy-1H-pyridin-2-one
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Anson
- Email: info@tianfuchem.com
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