PF-03654746 Tosylate

Modify Date: 2024-01-06 16:55:24

PF-03654746 Tosylate Structure
PF-03654746 Tosylate structure
Common Name PF-03654746 Tosylate
CAS Number 1039399-17-1 Molecular Weight 494.59400
Density N/A Boiling Point N/A
Molecular Formula C25H32F2N2O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PF-03654746 Tosylate


PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms[1]. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2].

 Names

Name N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane-1-carboxamide,4-methylbenzenesulfonic acid
Synonym More Synonyms

 PF-03654746 Tosylate Biological Activity

Description PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms[1]. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2].
Related Catalog
Target

H3 receptor[1]

References

[1]. Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2.

[2]. Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.

 Chemical & Physical Properties

Molecular Formula C25H32F2N2O4S
Molecular Weight 494.59400
Exact Mass 494.20500
PSA 98.58000
LogP 6.23310

 Synonyms

unii-v600i6h7t6
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