Uprosertib
Modify Date: 2024-01-03 16:32:07
Uprosertib structure
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Common Name | Uprosertib | ||
|---|---|---|---|---|
| CAS Number | 1047634-65-0 | Molecular Weight | 429.24800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16Cl2F2N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of UprosertibUprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively. |
| Name | N-[(2S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively. |
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| Related Catalog | |
| Target |
Akt1:180 nM (IC50) Akt2:328 nM (IC50) Akt3:38 nM (IC50) CDK7:2100 nM (IC50) ROCK1:1570 nM (IC50) ROCK2:1850 nM (IC50) |
| In Vitro | Uprosertib (GSK2141795) inhibits Akt1/2/3 with the Kd values of 16/49/5 nM, respectively. Uprosertib potently inhibits only the PKC family members PRKACA and PRKACB as well as the cGMP-dependent protein kinase PRKG1 aqpart from the Akts. Protein targets that bind Uprosertib (GSK2141795) in the lysate show a dose-dependent reduction in binding to the kinobeads, while proteins unaffected by the drug show no reduction in binding[1]. |
| References |
| Molecular Formula | C18H16Cl2F2N4O2 |
|---|---|
| Molecular Weight | 429.24800 |
| Exact Mass | 428.06200 |
| PSA | 86.08000 |
| LogP | 4.65610 |
| Storage condition | -20℃ |
| Uprosertib |
| GSK2141795 |