AC 264613
Modify Date: 2024-01-10 11:17:00
AC 264613 structure
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Common Name | AC 264613 | ||
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| CAS Number | 1051487-82-1 | Molecular Weight | 400.26900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H18BrN3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AC 264613AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC50 of 7.5[1]. |
| Name | (3R,4S)-N-[(E)-1-(3-bromophenyl)ethylideneamino]-2-oxo-4-phenylpyrrolidine-3-carboxamide |
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| Synonym | More Synonyms |
| Description | AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC50 of 7.5[1]. |
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| Related Catalog | |
| Target |
pEC50: 7.5 (PAR-2)[1] |
| In Vitro | AC-264613 (10 μM; for 6 hours) causes a decrease of IRF5 expression and also significantly reduces p53 protein expression in macrophages[2]. Western Blot Analysis[2] Cell Line: Granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent macrophages Concentration: 10 μM Incubation Time: 6 hours Result: Significantly decreased IRF5 expression and reduced p53 protein levels. |
| In Vivo | AC-264613 exhibits moderate elimination half-live (T1/2=2.5±2.0 h) following i.p. administration (10 mg/kg) in male Sprague-Dawley rats[3]. |
| References |
| Molecular Formula | C19H18BrN3O2 |
|---|---|
| Molecular Weight | 400.26900 |
| Exact Mass | 399.05800 |
| PSA | 77.54000 |
| LogP | 3.93530 |
| Storage condition | -20℃ |
| UNII-1ST2P4BE17 |
| 3-Pyrrolidinecarboxylic acid,2-oxo-4-phenyl-,2-(1-(3-bromophenyl)ethylidene)hydrazide,(3R,4S)-rel |
| AC 264613 |