alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol
Modify Date: 2024-02-07 16:27:09
alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol structure
|
Common Name | alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol | ||
|---|---|---|---|---|
| CAS Number | 105565-56-8 | Molecular Weight | 348.39000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H22F2N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanolBMY 14802 is a sigma-1 receptor (σ1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM[1][2]. |
| Name | 4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]-1-(4-fluorophenyl)butanol |
|---|---|
| Synonym | More Synonyms |
| Description | BMY 14802 is a sigma-1 receptor (σ1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Sigma 1 Receptor 5-HT1A Receptor α1-adrenergic receptor |
| In Vivo | BMY 14802 (15 mg/kg；腹腔注射；单次剂量) 在大鼠 PD 模型中显著抑制 AIM 并减少运动障碍，尤其是在处理后的第一个小时[1][2]。 |
| References |
| Molecular Formula | C18H22F2N4O |
|---|---|
| Molecular Weight | 348.39000 |
| Exact Mass | 348.17600 |
| PSA | 52.49000 |
| LogP | 2.39350 |
| 1-[4-(4-fluorophenyl)-4-hydroxybutyl]-4-(5-fluoropyrimidin-2-yl)-piperazine |
| α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine-butanol hydrochloride |
| BMS-181100 |
| α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol monohydrochloride |
| BMY-14802 |
| BMY 14802 |
| 1-(4-Fluoro-phenyl)-4-[4-(5-fluoro-pyrimidin-2-yl)-piperazin-1-yl]-butan-1-ol |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: 4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]-1-(4-fluorophenyl)butanol
- Price:
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Tom
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
Get all suppliers and price by the below link:
alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol suppliers
Price: ￥1000/5 mg
Reference only. check more alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol price