3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

Modify Date: 2024-01-06 09:21:47

3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione Structure
3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione structure
Common Name 3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
CAS Number 1061604-41-8 Molecular Weight 260.245
Density 1.5±0.1 g/cm3 Boiling Point 602.9±55.0 °C at 760 mmHg
Molecular Formula C13H12N2O4 Melting Point N/A
MSDS N/A Flash Point 318.4±31.5 °C

 Use of 3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione


Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC.

 Names

Name 3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
Synonym More Synonyms

  Biological Activity

Description Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC.
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 602.9±55.0 °C at 760 mmHg
Molecular Formula C13H12N2O4
Molecular Weight 260.245
Flash Point 318.4±31.5 °C
Exact Mass 260.079712
LogP -0.85
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.660
Storage condition 2-8℃

 Synonyms

MFCD29054753
3-(4-Hydroxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2,6-piperidinedione
2,6-Piperidinedione, 3-(1,3-dihydro-4-hydroxy-1-oxo-2H-isoindol-2-yl)-
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