O-Butyryl timolol

Modify Date: 2024-01-04 01:26:34

O-Butyryl timolol Structure
O-Butyryl timolol structure
Common Name O-Butyryl timolol
CAS Number 106351-79-5 Molecular Weight 386.51000
Density 1.169g/cm3 Boiling Point 511.5ºC at 760 mmHg
Molecular Formula C17H30N4O4S Melting Point N/A
MSDS N/A Flash Point 263.2ºC

 Use of O-Butyryl timolol


Butyryltimolol, an effective prodrug of Timolol, improves the corneal penetration of Timolol[1]. Butyryltimolol is a β-adrenergic blocker[2].

 Names

Name [(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-yl] butanoate
Synonym More Synonyms

 O-Butyryl timolol Biological Activity

Description Butyryltimolol, an effective prodrug of Timolol, improves the corneal penetration of Timolol[1]. Butyryltimolol is a β-adrenergic blocker[2].
Related Catalog
In Vitro Butyryltimolol, a prodrug of Timolol, is equally effective as 240-min nasolacrimal blockade in enhancing ocular drug absorption[1].
References

[1]. Chang SC, et al. Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol. Exp Eye Res. 1988 Jan;46(1):59-69.

[2]. Potter DE, et al. Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol. Curr Eye Res. 1988 Aug;7(8):755-9.

 Chemical & Physical Properties

Density 1.169g/cm3
Boiling Point 511.5ºC at 760 mmHg
Molecular Formula C17H30N4O4S
Molecular Weight 386.51000
Flash Point 263.2ºC
Exact Mass 386.19900
PSA 114.05000
LogP 2.30940
Vapour Pressure 1.41E-10mmHg at 25°C
Index of Refraction 1.522
Storage condition -20℃

 Synonyms

Timolol butyryl ester
Butyryl timolol
O-Butyryl timolol