ST-271

Modify Date: 2024-01-03 10:26:43

ST-271 Structure
ST-271 structure
Common Name ST-271
CAS Number 106392-48-7 Molecular Weight 272.34200
Density 1.137g/cm3 Boiling Point 468.4ºC at 760mmHg
Molecular Formula C16H20N2O2 Melting Point N/A
MSDS N/A Flash Point 237.1ºC

 Use of ST-271


ST271 is a potent inhibitor of protein tyrosine kinase (PTK).

 Names

Name (E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]prop-2-enamide
Synonym More Synonyms

 ST-271 Biological Activity

Description ST271 is a potent inhibitor of protein tyrosine kinase (PTK).
Related Catalog
In Vitro ST271 partially inhibits peptide phosphorylation in the membrane preparation and in permeabilized platelets[1]. ST271 (100 μM) causes complete inhibition of formation of inositol phosphates induced by FcγRII cross-linking, but also induces a small (< 30%) but significant inhibition of the response to thrombin and U46619[2].
References

[1]. Martinson EA, et al. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors. Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):627-34.

[2]. Blake RA, et al. Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor.

 Chemical & Physical Properties

Density 1.137g/cm3
Boiling Point 468.4ºC at 760mmHg
Molecular Formula C16H20N2O2
Molecular Weight 272.34200
Flash Point 237.1ºC
Exact Mass 272.15200
PSA 88.10000
LogP 4.18098
Appearance of Characters light yellow solid
Vapour Pressure 2.14E-09mmHg at 25°C
Index of Refraction 1.585
Storage condition -20℃

 Safety Information

HS Code 2926909090

 Customs

HS Code 2926909090
Summary HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

st 271
ST-271
ST271
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