CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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GH1575000
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CHEMICAL NAME :
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Colistin
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CAS REGISTRY NUMBER :
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1066-17-7
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LAST UPDATED :
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199806
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DATA ITEMS CITED :
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14
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MOLECULAR FORMULA :
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C45-H85-N13-O10
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MOLECULAR WEIGHT :
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968.43
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WISWESSER LINE NOTATION :
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T-24-MV DMV GMV JMV MMV PMV SMV VMVTJ CYQ1 F2MV4Y2&1 I1Y1&1 L2Z O1Y1&1 R2Z U2Z A&2Z
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>2 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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236 mg/kg
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TOXIC EFFECTS :
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Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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115 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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8800 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Mammal - cat
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DOSE/DURATION :
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250 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - nausea or vomiting
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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100 mg/kg
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - flaccid paralysis with appropriate anesthesia Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Mammal - cat
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DOSE/DURATION :
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1500 mg/kg/30D-I
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
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TYPE OF TEST :
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Cytogenetic analysis
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TEST SYSTEM :
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Human Lymphocyte
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DOSE/DURATION :
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142 units/ml
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REFERENCE :
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TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 3,515,1983 *** REVIEWS *** TOXICOLOGY REVIEW MMWOAU Muenchener Medicinische Wochenschrift. (Munich, Fed. Rep. Ger.) V.33-115, 1886-1973. Volume(issue)/page/year: 115,1661,1973 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5828 No. of Facilities: 143 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1941 (estimated) No. of Female Employees: 1403 (estimated)
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