Olprinone structure
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Common Name | Olprinone | ||
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CAS Number | 106730-54-5 | Molecular Weight | 250.255 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C14H10N4O | Melting Point | >300ºC | |
MSDS | N/A | Flash Point | N/A |
Use of OlprinoneOlprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury. |
Name | 5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile |
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Synonym | More Synonyms |
Description | Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury. |
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Related Catalog | |
References |
Density | 1.3±0.1 g/cm3 |
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Melting Point | >300ºC |
Molecular Formula | C14H10N4O |
Molecular Weight | 250.255 |
Exact Mass | 250.085464 |
PSA | 73.95000 |
LogP | 1.03 |
Index of Refraction | 1.703 |
Hazard Codes | T,N,C |
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Risk Phrases | R25:Toxic if swallowed. R34:Causes burns. R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . R24/25:Toxic in contact with skin and if swallowed . R36:Irritating to the eyes. |
Safety Phrases | S26-S36-S45-S61-S36/37/39 |
RIDADR | UN 2922 8/PG 2 |
WGK Germany | 3 |
RTECS | AK5110000 |
Packaging Group | II |
Hazard Class | 8 |
HS Code | 29183000 |
~51% Olprinone CAS#:106730-54-5 |
Literature: Yamanaka; Miyake; Suda; Ohhara; Ogawa Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567 |
~% Olprinone CAS#:106730-54-5 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567 |
~% Olprinone CAS#:106730-54-5 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567 |
~% Olprinone CAS#:106730-54-5 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567 |
~% Olprinone CAS#:106730-54-5 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567 |
~% Olprinone CAS#:106730-54-5 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567 |
~% Olprinone CAS#:106730-54-5 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567 |
~% Olprinone CAS#:106730-54-5 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567 |
Precursor 9 | |
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DownStream 0 |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxonicotinonitrile |
Olprinone [INN] |
1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile |
5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile |
UNII-4Y8BMI9YGC |
Loprinone |
Coretec |
3-Pyridinecarbonitrile, 1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo- |
MFCD00868774 |
Olprinone |
1,2-dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile |
5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile |
Olprinone| |