Samalizumab

Modify Date: 2024-01-02 20:49:39

Samalizumab Structure
Samalizumab structure
Common Name Samalizumab
CAS Number 1073059-33-2 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Samalizumab


Samalizumab (ALXN 6000) is a humanized monoclonal antibody that specifically binds to CD200 and blocks its ligation to the CD200 receptor (CD200R). Samalizumab can be used for multiple myeloma and B-cell chronic lymphocytic leukemia research[1].

 Names

Name Samalizumab

 Samalizumab Biological Activity

Description Samalizumab (ALXN 6000) is a humanized monoclonal antibody that specifically binds to CD200 and blocks its ligation to the CD200 receptor (CD200R). Samalizumab can be used for multiple myeloma and B-cell chronic lymphocytic leukemia research[1].
Related Catalog
In Vitro Samalizumab 被合理设计为具有 Ig G2/G4 恒定区,以最大限度地减少效应子功能并保护免疫细胞亚群。Samalizumab 是一种重组人源化抗 CD200 单抗,旨在消除效应子功能,特异性结合免疫检查点 CD200,阻断受体参与和信号传导,并拮抗 CD200 驱动的免疫抑制,从而发挥抗肿瘤作用免疫反应[1]。
References

[1]. Daruka Mahadevan, et al. Phase I study of samalizumab in chronic lymphocytic leukemia and multiple myeloma: blockade of the immune checkpoint CD200. J Immunother Cancer. 2019 Aug 23;7(1):227.  

 Chemical & Physical Properties

No Any Chemical & Physical Properties