ST638

Modify Date: 2024-01-31 12:03:37

ST638 Structure
ST638 structure
Common Name ST638
CAS Number 107761-24-0 Molecular Weight 354.423
Density 1.3±0.1 g/cm3 Boiling Point 611.2±55.0 °C at 760 mmHg
Molecular Formula C19H18N2O3S Melting Point 134-135.5ºC
MSDS Chinese USA Flash Point 323.5±31.5 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of ST638


ST638 is a potent tyrosine kinase inhibitor with an IC50 of 370 nM[1].

 Names

Name 2-cyano-3-[3-ethoxy-4-hydroxy-5-(phenylsulfanylmethyl)phenyl]prop-2-enamide
Synonym More Synonyms

 ST638 Biological Activity

Description ST638 is a potent tyrosine kinase inhibitor with an IC50 of 370 nM[1].
Related Catalog
References

[1]. Fuortes M, et al. Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor. J Cell Biol. 1993 Feb;120(3):777-84.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 611.2±55.0 °C at 760 mmHg
Melting Point 134-135.5ºC
Molecular Formula C19H18N2O3S
Molecular Weight 354.423
Flash Point 323.5±31.5 °C
Exact Mass 354.103821
PSA 121.64000
LogP 2.34
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.656

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UC6316200
CHEMICAL NAME :
2-Propenamide, 2-cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)p henyl)-
CAS REGISTRY NUMBER :
107761-24-0
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C19-H18-N2-O3-S
MOLECULAR WEIGHT :
354.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-00938
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-00938

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UC6316200
HS Code 2930909090

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles25

More Articles
The effect of a naphthalene derivative, TEI-6472, on histamine release and tyrosine phosphorylation in rat basophilic leukemia cells.

Int. J. Immunopharmacol. 17(5) , 433-41, (1995)

It is well known that rat basophilic leukemia cells (RBL-2H3) express high-affinity IgE receptors (Fc epsilon RI) and that the aggregation of these receptors causes the release of chemical mediators. ...

Inhibition of fast sodium current in rabbit ventricular myocytes by protein tyrosine kinase inhibitors.

Pflugers Arch. 446(4) , 485-91, (2003)

The present study investigated the effects of protein tyrosine kinase inhibitors on the fast sodium current ( I(Na)) in rabbit ventricular myocytes. Single rabbit ventricular myocytes were isolated en...

Involvement of phosphatidic acid in both degranulation and oxidative activity in fMet-Leu-Phe stimulated polymorphonuclear leukocytes.

Cell Physiol. Biochem. 13(3) , 165-72, (2003)

Polymorphonuclear leukocytes (neutrophils) release a variety of toxic agents--proteins and reactive oxygen species (ROS)--that are used to inactivate foreign microorganisms in the non-specific immune ...

 Synonyms

2-Propenamide, 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]-, (2E)-
MFCD00236446
(2E)-2-Cyano-3-{3-ethoxy-4-hydroxy-5-[(phenylsulfanyl)methyl]phenyl}acrylamide
ST638 (pharmaceutical)
2-Propenamide,2-cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]
ST 638
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