DC_C66

Modify Date: 2024-01-10 13:35:02

DC_C66 structure	Common Name	DC_C66
	CAS Number	108181-00-6	Molecular Weight	404.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₂NO₂+	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DC_C66

DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5[1].

Name	DC_C66

Description	DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	IC50: 1.8 μM (CARM1)[1]
In Vitro	DC_C66 (6.25-100 μM; 24-72 hours) exhibits antiproliferation activity in several CARM1-associated cancer cell lines[1]. Cell Proliferation Assay[1] Cell Line: HELA, K562, MCF7 cells Concentration: 6.25, 12.5, 25, 50, 100 μM Incubation Time: 24, 48, 72 hours Result: Inhibits proliferation of cancer cells in a time-dependent and dose-dependent manner in HELA, K562, and MCF7 cells.
References	[1]. Ye F, et al. Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays. Biomed Res Int. 2016;2016:7086390.

Molecular Formula	C₂₈H₂₂NO₂+
Molecular Weight	404.48

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DC_C66
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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