G 28UCM

Modify Date: 2024-01-05 08:54:24

G 28UCM Structure
G 28UCM structure
Common Name G 28UCM
CAS Number 1094451-90-7 Molecular Weight 464.378
Density 1.7±0.1 g/cm3 Boiling Point 895.1±65.0 °C at 760 mmHg
Molecular Formula C24H16O10 Melting Point N/A
MSDS N/A Flash Point 313.3±27.8 °C

 Use of G 28UCM


UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines[1]. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli[2].

 Names

Name 1,3-Naphthalenediyl bis(3,4,5-trihydroxybenzoate)
Synonym More Synonyms

 G 28UCM Biological Activity

Description UCM05 (G28UCM) is a potent inhibitor of fatty acid synthase (FASN) shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines[1]. UCM05 is a Filamentous temperature-sensitive protein Z (FtsZ) inhibitor and inhibits the growth of the Gram-positive bacterium B. subtilis with MIC values of 100 μM but lack activity on the Gram-negative bacterium E. coli[2].
Related Catalog
References

[1]. Teresa Puig, et al. A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 2011;13(6):R131.

[2]. Swayansiddha Tripathy, et al. FtsZ inhibitors as a new genera of antibacterial agents. Bioorg Chem. 2019 Oct;91:103169.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 895.1±65.0 °C at 760 mmHg
Molecular Formula C24H16O10
Molecular Weight 464.378
Flash Point 313.3±27.8 °C
Exact Mass 464.074341
LogP 4.63
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.787
Storage condition -20°C

 Synonyms

1,3-Naphthalenediyl bis(3,4,5-trihydroxybenzoate)
Benzoic acid, 3,4,5-trihydroxy-, 1,3-naphthalenediyl ester