RX 821002 hydrochloride
RX 821002 hydrochloride structure
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Common Name | RX 821002 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 109544-45-8 | Molecular Weight | 270.71200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H15ClN2O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of RX 821002 hydrochloride2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2)[1][2]. |
| Name | 2-(3-methoxy-2H-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | 2-Methoxyidazoxan monohydrochloride (RX821002 hydrochloride) is a highly selective alpha 2-adrenoceptor antagonist with little or no imidazoline antagonist effect. RX 821002 has markedly higher affinity for (guinea-pig) alpha 2D-adrenoceptors (pKd 9.7) than for (rabbit) alpha 2A-adrenoceptors (pKd 8.2)[1][2]. |
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| Related Catalog | |
| In Vivo | 2-Methoxyidazoxan monohydrochloride (1 mg/kg) enhances locomotion in the novel environment, particularly in neonatal ventral hippocampal lesion (NVHL) rats. RX82100 has a biphasic effect on locomotion, consisting of an initial reduction preceding the enhancement[3]. |
| References |
| Molecular Formula | C12H15ClN2O3 |
|---|---|
| Molecular Weight | 270.71200 |
| Exact Mass | 270.07700 |
| PSA | 52.08000 |
| LogP | 1.36860 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
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Role of the bed nucleus of the stria terminalis in the cardiovascular responses to acute restraint stress in rats.
Stress 12(3) , 268-78, (2009) The aim of this work was to test the hypothesis that the bed nucleus of the stria terminalis (BST) and noradrenergic neurotransmission therein mediate cardiovascular responses to acute restraint stres... |
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Disruption of noradrenergic transmission and the behavioural response to a novel environment in NK1R-/- mice.
Eur. J. Neurosci. 25(4) , 1195-204, (2007) The behaviour of neurokinin-1-receptor gene knockout (NK1R-/-) mice, which lack functional, substance P-preferring receptors, resembles that of NK1R+/+ mice treated with an antidepressant. Because all... |
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Adrenergic mechanisms of the Kölliker-Fuse/A7 area on the control of water and sodium intake.
Neuroscience 164(2) , 370-9, (2009) The blockade of serotoninergic receptors with methysergide or the activation of alpha(2)-adrenoceptors with moxonidine into the lateral parabrachial nucleus (LPBN) increases water and 0.3 M NaCl intak... |
| RX 821002 hydrochloride |