Ginsenoside Rc

Modify Date: 2024-01-02 17:30:57

Ginsenoside Rc Structure
Ginsenoside Rc structure
Common Name Ginsenoside Rc
CAS Number 11021-14-0 Molecular Weight 1079.269
Density 1.4±0.1 g/cm3 Boiling Point 1128.3±65.0 °C at 760 mmHg
Molecular Formula C53H90O22 Melting Point N/A
MSDS Chinese USA Flash Point 636.2±34.3 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Ginsenoside Rc


Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β.

 Names

Name ginsenoside Rc
Synonym More Synonyms

 Ginsenoside Rc Biological Activity

Description Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β.
Related Catalog
Target

GABA Receptor

TNF-α

IL-1β

In Vitro Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptorA (GABAA)-mediated ion channel currents. Ginsenoside Rc enhances GABA-mediated ion currents in oocytes expressing the GABAA receptor[1]. Ginsenoside Rc significantly inhibits the expression of macrophage-derived cytokines, such as TNF-α and IL-1β. Ginsenoside Rc also markedly suppresses the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Ginsenoside Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling. Ginsenoside Rc suppresses the nuclear translocation of phospho-ATF-2 and phospho-FRA-1, whereas the translocation of p65 at its peak time points (30 and 60 min) is not decreased by Ginsenoside Rc treatment. Ginsenoside Rc regulates the expression of the proinflammatory cytokine TNF-α, which is produced by macrophages, by suppressing AP-1 activation[2].
Kinase Assay To evaluate the effects of Ginsenoside Rc on kinase activity, immunoprecipitated TBK1, IKKε, and p38 are incubated in reaction buffer in the presence or absence of Ginsenoside Rc. The reactions are initiated by the addition of Mg-ATP. After a 30 min incubation at 30°C, the reactions are stopped by the addition of sample buffer and the samples are boiled. Kinase activity is assessed by immunoblotting with antibodies against the phospho-forms of IKKε, IRF-3, and ATF-2[2].
References

[1]. Lee BH, et al. Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents. J Ginseng Res. 2012 Jan;36(1):55-60.

[2]. Yu T, et al. Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-bindingkinase 1/interferon regulatory factor-3 and p38/ATF-2. J Ginseng Res. 2017 Apr;41(2):127-133.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 1128.3±65.0 °C at 760 mmHg
Molecular Formula C53H90O22
Molecular Weight 1079.269
Flash Point 636.2±34.3 °C
Exact Mass 1078.592407
PSA 357.06000
LogP 5.10
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.622
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LY9536300
CHEMICAL NAME :
Ginsenoside RC
CAS REGISTRY NUMBER :
11021-14-0
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C53-H90-O22
MOLECULAR WEIGHT :
1079.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
410 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
50 mg/kg
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2400,1976

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS LY9536300

 Synthetic Route

~%

Ginsenoside Rc Structure

Ginsenoside Rc

CAS#:11021-14-0

Literature: Kitagawa; Taniyama; Yoshikawa; Ikenishi; Nakagawa Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 11 p. 2961 - 2970

~%

Ginsenoside Rc Structure

Ginsenoside Rc

CAS#:11021-14-0

Literature: Chemical and Pharmaceutical Bulletin, , vol. 37, # 11 p. 2961 - 2970

 Precursor & DownStream

Precursor  1

DownStream  0

 Articles23

More Articles
[A quantitative method using one marker for simultaneous assay of ginsenosides in Panax ginseng and P. notoginseng].

Yao Xue Xue Bao 43(12) , 1211-6, (2008)

Current quality control patterns are limited to industrial application, for most of the natural chemical reference substances are expensive and unavailable. Herein, a method, quantitative analysis of ...

Microbial transformation of ginsenosides Rb1, Rb3 and Rc by Fusarium sacchari.

J. Appl. Microbiol. 109(3) , 792-8, (2010)

This study examined the transformation pathways of ginsenosides G-Rb(1) , G-Rb(3) , and G-Rc by the fungus Fusarium sacchari.Ginsenosides G-Rb(1) , G-Rb(3) and G-Rc were isolated from leaves of Radix ...

[Chemical constituents of flower-buds of Panax ginseng--isolation and identification of ginsenoside-Rb3 and ginsenoside-Rc].

Zhong Yao Tong Bao 9(4) , 172-3, (1984)

 Synonyms

EINECS 234-253-5
Ginsenoside Rc
(3β,12β)-20-{[6-O-(α-L-Arabinofuranosyl)-β-D-glucopyranosyl]oxy}-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
β-D-Glucopyranoside, (3β,12β)-20-[(6-O-α-L-arabinofuranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-
20-((6-O-α-L-Arabinofuranosyl-β-D-glucopyranosyl)oxy)-12β-hydroxydammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
MFCD00133368
Ginsenoside-Rc from Panax ginseng (Korean ginseng) root
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