1-Octanol

Modify Date: 2024-01-02 23:03:10

1-Octanol structure	Common Name	1-Octanol
	CAS Number	111-87-5	Molecular Weight	130.22800
	Density	0.827 g/mL at 25 °C(lit.)	Boiling Point	196 °C(lit.)
	Molecular Formula	C₈H₁₈O	Melting Point	−15 °C(lit.)
	MSDS	Chinese USA	Flash Point	178 °F
	Symbol	GHS07	Signal Word	Warning

Use of 1-Octanol

1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[1]. 1-Octanol is a highly attractive biofuel with diesel-like properties[2].

Name	octan-1-ol
Synonym	More Synonyms

Description	1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[1]. 1-Octanol is a highly attractive biofuel with diesel-like properties[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	T-type calcium channel:4 μM (IC50) Human Endogenous Metabolite
In Vitro	1-octanol inhibits native T-currents at subanesthetic concentrations with an IC50 of approximately 4 μM. In contrast, 1-octanol is up to 30-fold less potent in inhibiting recombinant CaV3.3 T-channels heterologously expressed in human embryonic kidney cells[1].
References	[1]. Joksovic PM, et al. Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway. Mol Pharmacol. 2010 Jan;77(1):87-94. [2]. Akhtar MK, et al. Microbial production of 1-octanol: A naturally excreted biofuel with diesel-like properties. Metab Eng Commun. 2014 Nov 13;2:1-5.

Density	0.827 g/mL at 25 °C(lit.)
Boiling Point	196 °C(lit.)
Melting Point	−15 °C(lit.)
Molecular Formula	C₈H₁₈O
Molecular Weight	130.22800
Flash Point	178 °F
Exact Mass	130.13600
PSA	20.23000
LogP	2.33920
Vapour density	4.5 (vs air)
Vapour Pressure	0.14 mm Hg ( 25 °C)
Index of Refraction	n20/D 1.429(lit.)
Stability	Stable. Flammable. Incompatible with strong oxidizing agents.
Water Solubility	insoluble

1-Octanol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RH6550000

CHEMICAL NAME :: Octyl alcohol

CAS REGISTRY NUMBER :: 111-87-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C8-H18-O

MOLECULAR WEIGHT :: 130.26

WISWESSER LINE NOTATION :: Q8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5600 mg/m3/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 69 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 1240 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 800 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80235 No. of Facilities: 1071 (estimated) No. of Industries: 29 No. of Occupations: 32 No. of Employees: 13905 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80235 No. of Facilities: 9310 (estimated) No. of Industries: 133 No. of Occupations: 93 No. of Employees: 287737 (estimated) No. of Female Employees: 72792 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319-H412
Precautionary Statements	P273-P280-P305 + P351 + P338-P337 + P313
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R36/38
Safety Phrases	S26-S36/37-S37/39
RIDADR	3082
WGK Germany	1
RTECS	RH6550000
Packaging Group	III
Hazard Class	9
HS Code	2905161000

Precursor 10
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CAS#:629-05-0 Oct-1-yne CAS#:6998-10-3 Octanamide, N-p... CAS#:3208-43-3 4-(2-tetrahydro... CAS#:124-07-2 Octanoic acid
CAS#:124-13-0 Octanal CAS#:92976-53-9 tert-butyl-dime...
DownStream 10
CAS#:106144-21-2 4-octoxybenzene... CAS#:104483-29-6 ethenyl octyl c... CAS#:100386-17-2 octyl 2-hydroxy... CAS#:94-50-8 octyl benzoate
CAS#:10348-34-2 2-methylundecan-4-ol CAS#:104483-19-4 octyl carbonofl... CAS#:109-36-4 octyl stearate CAS#:32953-65-4 octyl oleate
CAS#:67-56-1 Methanol CAS#:1071-67-6 octyl N-butylca...

HS Code	2905161000

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1-Octanol
Price: Click To Check
Purity: 99.5%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1-Octanol
Price: ￥98.0/500ml
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Octanol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFUCHEM--High purity 111-87-5 1-Octanol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: ￥1720/10 mM * 1 mL in DMSO

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1-Octanol

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