Annonacin

Modify Date: 2024-01-10 18:44:52

Annonacin Structure
Annonacin structure
 Common Name Annonacin
CAS Number 111035-65-5 Molecular Weight 596.878
Density 1.0±0.1 g/cm3 Boiling Point 756.2±55.0 °C at 760 mmHg
Molecular Formula C35H64O7 Melting Point N/A
MSDS N/A Flash Point 227.0±25.0 °C

 Use of Annonacin


Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex. Annonacin is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pumps[1].

 Names

Name (2S)-2-methyl-4-[(2R,8R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-5-[(1R)-1-hydroxytridecyl]oxolan-2-yl]tridecyl]-2H-furan-5-one
Synonym More Synonyms

 Annonacin Biological Activity

Description Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex. Annonacin is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pumps[1].
Related Catalog
References

[1]. Yiallouris A, et al. Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways. Cell Death Dis. 2018 Jul 9;9(7):764.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 756.2±55.0 °C at 760 mmHg
Molecular Formula C35H64O7
Molecular Weight 596.878
Flash Point 227.0±25.0 °C
Exact Mass 596.465210
PSA 116.45000
LogP 6.36
Vapour Pressure 0.0±5.8 mmHg at 25°C
Index of Refraction 1.506

 Safety Information

Hazard Codes Xi

 Synonyms

annonacin A
Annonacin
2(5H)-Furanone, 5-methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-tetrahydro-5-[(1R)-1-hydroxytridecyl]-2-furanyl]tridecyl]-, (5S)-
(5S)-5-Methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-{(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydro-2-furanyl}tridecyl]-2(5H)-furanone
(5S)-5-methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-{(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydrofuran-2-yl}tridecyl]furan-2(5H)-one
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Related Compounds: More...
annonacin A
130853-76-8
Annonacinone
123266-21-7
Isoannonacin
170900-30-8
Chemsrc provides Annonacin(CAS#:111035-65-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Annonacin are included as well.>> amp version: Annonacin

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