Ponatinib hydrochloride
Modify Date: 2024-01-06 11:44:41
Ponatinib hydrochloride structure
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Common Name | Ponatinib hydrochloride | ||
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| CAS Number | 1114544-31-8 | Molecular Weight | 569.02 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H28ClF3N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ponatinib hydrochloridePonatinib (AP24534) hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1]. |
| Name | 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide,hydrochloride |
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| Synonym | More Synonyms |
| Description | Ponatinib (AP24534) hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1]. |
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| Related Catalog | |
| Target |
VEGFR2:1.5 nM (IC50) FGFR1:2.2 nM (IC50) PDGFRα:1.1 nM (IC50) Abl:0.37 nM (IC50) LYN:0.24 nM (IC50) Src:5.4 nM (IC50) |
| References |
| Molecular Formula | C29H28ClF3N6O |
|---|---|
| Molecular Weight | 569.02 |
| Exact Mass | 568.196533 |
| PSA | 65.77000 |
| LogP | 5.20680 |
| Hazard Codes | Xn |
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| 3-(Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}benzamide hydrochloride (1:1) |
| Benzamide, 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-, hydrochloride (1:1) |
| Iclusig (TN) |
| UNII-96R6PU3D8J |
| Ponatinib hydrochloride (USAN) |
| AP 24534 hydrochloride |
| Ponatinib hydrochloride |
| 96R6PU3D8J |
| Ponatinib HCl |